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Disease

Keratoconus

Late-stage therapeutic developmentEmerging research
MeSHKeratoconus
2
Publications
16
Clinical trials
12
Associated genes
2
Related proteins
2022
Latest publication
Current focus
Lysine 6-oxidase biologyTherapeutic developmentInflammation & immunityDisease mechanisms & pathology
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Keratoconus: An updated review.

Research2022-01-04Contact lens & anterior eye : the journal of the British Contact Lens Association

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults.

Research2016-01-10Oxidative medicine and cellular longevity

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q2 2027.
  • 4 industry developments reported.
Upcoming Milestones
Clinical Milestones4View
Results posted 1
Results expected 2
Recently completed 1
Industry & Market4View
Activity timeline8

Clinical trials

11 sponsors · 2 new · 0 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
16
All trials
3
Active
12
Late-stage
6
Completed
Late-stage studies

Single-arm, Multi-center Study to Evaluate the Safety and Feasibility of Bilateral Epithelium-on Corneal Collagen Cross-linking With Epioxa™ HD/Epioxa™ and UV-A Irradiation Using the O2n™ System and Supplemental Oxygen Using the Boost Goggles® in Subjects With Keratoconus

Phase 4 · Recruiting · Glaukos Corporation

Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus: A Randomized Clinical Trial

Phase 3 · Recruiting · University of Campinas, Brazil

Prospective Randomised Corneal Crosslinking Study

Phase 4 · Completed · Region Skane

A Phase III, Multi-center Study to Evaluate the Safety and Efficacy of Epithelium-on Corneal Collagen Cross-linking in Eyes With Progressive Keratoconus

Phase 3 · Completed · Glaukos Corporation

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Phase 4 · Completed · Sight Medical Doctors PLLC

Effect-evaluation of an Accelerated Corneal Cross-linking Protocol With Different Riboflavin Solutions

Phase 3 · Completed · Medical University of Vienna
Recently completed

Prospective Randomised Corneal Crosslinking Study

Phase 4 · Completed · Region Skane

Intracanalicular Dexamethasone Insert for Post-Corneal Cross-Linking Inflammation and Pain- The LINK Study

Phase 4 · Completed · Sight Medical Doctors PLLC

Safety and Efficacy of Intracanalicular Dexamethasone Insert Compared to Loteprednol Etabonate Ophthalmic Gel 0.38% in Patients With Keratoconus Wearing Gas Permeable Contact Lenses Who Have Been Diagnosed With Allergic Conjunctivitis

Early Phase 1 · Completed · Illinois College of Optometry

Effect-evaluation of an Accelerated Corneal Cross-linking Protocol With Different Riboflavin Solutions

Phase 3 · Completed · Medical University of Vienna

A Phase III, Multi-center Study to Evaluate the Safety and Efficacy of Epithelium-on Corneal Collagen Cross-linking in Eyes With Progressive Keratoconus

Phase 3 · Completed · Glaukos Corporation

Epithelium-On Corneal Collagen Crosslinking for Keratoconus

Phase 4 · Completed · Comprehensive EyeCare of Central Ohio

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20162022
Most influential

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults.

Oxidative medicine and cellular longevity · 2016 · 838 cites

Keratoconus: An updated review.

Contact lens & anterior eye : the journal of the British Contact Lens Association · 2022 · 420 cites
Recent publications

Keratoconus: An updated review.

Contact lens & anterior eye : the journal of the British Contact Lens Association · 2022 · 420 cites

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults.

Oxidative medicine and cellular longevity · 2016 · 838 cites
Major themes3
  • Contact Lenses1
  • Keratoconus1
  • Oxidative Stress1
Leading journals2
  • Contact lens & anterior eye : the journal of the British Contact Lens Association1
  • Oxidative medicine and cellular longevity1
Leading researchers8
  • Carracedo G1
  • Grzybowski A1
  • Nita M1
  • Santodomingo-Rubido J1
  • Suzaki A1
  • Villa-Collar C1
  • Vincent SJ1
  • Wolffsohn JS1
Affiliations (unnormalised)5
  • Clinical Research and Development Center1
  • Contact Lens and Visual Optics Laboratory1
  • Domestic and Specialized Medicine Centre "Dilmed"1
  • Poznan City Hospital1
  • School of optometry1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

TUBA3D0.47COL5A10.45VSX10.45COL12A10.44ALDH3A10.38LOX0.33GALNT60.33TMEM2120.33PTGDS0.32PSD30.30STK350.29AIFM30.28

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Protein-lysine 6-oxidasevia LOX0.33Killer cell immunoglobulin-like receptor 2DL1via KIR2DL10.11

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A noninflammatory, usually bilateral protrusion and thinning of the CORNEA, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. Two closely related noninflammatory corneal ectasias are pellucid marginal degeneration and keratoglobus.

Identifiers
MeSHKeratoconus
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.