Klebsiella Infections
Recent clinical, regulatory, research and industry developments relating to this disease.
Klebsiella pneumoniae emerging anti-immunology paradigms: from stealth to evasion.
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Klebsiella pneumoniae: an increasing threat to public health.
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What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Klebsiella Infections3
- Klebsiella pneumoniae3
- Host-Pathogen Interactions2
- Cross Infection1
- Gastrointestinal Microbiome1
- Immune Evasion1
- Public Health1
- Salmonella Infections1
Leading journals5
- Annals of clinical microbiology and antimicrobials1
- Nature communications1
- Science (New York, N.Y.)1
- The Journal of cell biology1
- Trends in microbiology1
Leading researchers8
- Abbott IJ1
- B N Araujo E1
- Bakkeren E1
- Bengoechea JA1
- Calderón-González R1
- Cunrath O1
- Effah CY1
- Foster KR1
Affiliations (unnormalised)6
- Australian and New Zealand Intensive Care Research Centre1
- Caulfield Hospital1
- Central Clinical School1
- College of Public Health1
- Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity1
- Graduate School of Engineering1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Klebsiella infections are infections caused by bacteria in the genus Klebsiella. The grounding emphasizes Klebsiella pneumoniae as a major nosocomial pathogen and a growing public health threat, with attention to its epidemiology, microbiology, and immunology.
The cause is infection with bacteria of the genus Klebsiella, particularly Klebsiella pneumoniae in the supplied literature. The grounding also highlights drug-resistant and virulent genes as important features of these organisms, but does not support more specific aetiologic detail.
The literature describes host-pathogen interactions in which Klebsiella exploits coevolution with the innate immune system. It can hijack immune effectors and receptors to disrupt signaling pathways and counteract cell-intrinsic immunity, helping the pathogen persist in tissues despite an activated immune response.
The supplied review identifies epidemiological risk factors for Klebsiella pneumoniae infection, especially in nosocomial settings. It also indicates that multidrug-resistant strains are an important context for disease burden, but does not provide specific patient-level risk factors in the grounding.
The grounding supports treatment at the level of antimicrobial therapy guided by resistance patterns, with attention to drug-resistant strains. It also implies that management is shaped by the organism's resistance profiles and virulence features, but does not provide specific regimens or modalities beyond this.
AI-generated summary grounded in MeSH and 2 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Infections with bacteria of the genus KLEBSIELLA.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.