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Disease

Leiomyoma

Late-stage therapeutic developmentEmerging research
MeSHLeiomyoma
2
Publications
15
Clinical trials
8
Associated genes
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Letrozole for Treatment of Uterine Fibroids: A Randomized, Placebo-Controlled Trial
Results expected Q3 20282026-07-22
Major trial resultsImportant
Intra-Arterial Dexamethasone for the Alleviation of Pain and Postembolization Syndrome Following Uterine Artery Embolization
Results posted2026-01-07
Clinical Milestones5View
Results posted 1
Results expected 2
Recently completed 2
Activity timeline5

Clinical trials

15 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
15
All trials
4
Active
11
Late-stage
6
Completed
Late-stage studies

Letrozole for Treatment of Uterine Fibroids: A Randomized, Placebo-Controlled Trial

Phase 4 · Recruiting · University of California, San Francisco

Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea (FRIEND)

Phase 3 · Active, not recruiting · Yale University

Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma

Phase 2/3 · Completed · Ain Shams University

A Phase III Confirmatory Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia

Phase 3 · Completed · Kissei Pharmaceutical Co., Ltd.

Efficacy of Transcervical Vasopressin Injection VersusVaginal Misoprostol During Hysteroscopic Myomectomy in Reducing Operative Blood Loss and Operation Time: A Randomized Trial.

Phase 2/3 · Completed · Zagazig University

Intra-Arterial Dexamethasone for the Alleviation of Pain and Postembolization Syndrome Following Uterine Artery Embolization

Phase 3 · Completed · University of Miami
Recently completed

Intra-Arterial Dexamethasone for the Alleviation of Pain and Postembolization Syndrome Following Uterine Artery Embolization

Phase 3 · Completed · University of Miami

Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma

Phase 2/3 · Completed · Ain Shams University

A Phase III Confirmatory Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia

Phase 3 · Completed · Kissei Pharmaceutical Co., Ltd.

An International Phase 3 Double-Blind, Placebo-Controlled, Randomized Withdrawal Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids

Phase 3 · Completed · Myovant Sciences GmbH

A Randomized Control Trial of Combined Vaginal Misoprostol and Perivascular Vasopressin During Robotic Myomectomy

Phase 4 · Completed · Antonios Likourezos

Efficacy of Transcervical Vasopressin Injection VersusVaginal Misoprostol During Hysteroscopic Myomectomy in Reducing Operative Blood Loss and Operation Time: A Randomized Trial.

Phase 2/3 · Completed · Zagazig University

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20232024
Major themes2
  • Leiomyoma2
  • Genome-Wide Association Study1
Leading journals1
  • Nature communications2
Leading researchers8
  • Abdula F2
  • Adli M2
  • Buyukcelebi K2
  • Duval AJ2
  • Elkafas H2
  • Seker-Polat F2
  • Bulun SE1
  • Chen X1
Affiliations (unnormalised)3
  • Robert Lurie Comprehensive Cancer Center2
  • Feinberg School of Medicine Northwestern University1
  • Northwestern University Feinberg School of Medicine1

Associated genes

8 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

HMGA20.40CCNB1IP10.37NUTM2B0.37WASHC30.13HRCT10.09CELA3A0.03MTMR80.01TBC1D130.00

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.

Identifiers
MeSHLeiomyoma
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.