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Disease

Lentigo

Late-stage therapeutic developmentEmerging research
MeSHLentigo
1
Publications
10
Clinical trials
1998
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones (1 completed or reporting results).
Major developments
Major trial resultsHigh impact
A Phase II Trial of SCH 727965 (NSC 747135) in Patients With Stage IV Melanoma
Results posted2026-05-29
Clinical Milestones1View
Results posted 1
Activity timeline1

Clinical trials

7 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
10
All trials
1
Active
4
Late-stage
6
Completed
Recently completed

A Randomised Controlled Multicentre Trial of Imiquimod Versus Radiotherapy for Lentigo Maligna (LM) When Staged Surgical Excision With 5mm Margins is Not Possible, is Refused, or Fails

Phase 3 · Completed · Melanoma and Skin Cancer Trials Limited

Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face - Study PICAMEL

Phase 2 · Completed · Centre Hospitalier Universitaire de Nice

Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face

Phase 3 · Completed · Nantes University Hospital

Photodynamic Therapy for Melanoma Precursor Lesion Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion (BF-200 ALA) as a Light Sensitizing Cream

Phase 4 · Completed · Joint Authority for Päijät-Häme Social and Health Care

Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna

N/A · Completed · University of Utah

Effect of Topical Imiquimod on Lentigo Maligna

Phase 4 · Completed · Jerry Marsden

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Leading journals1
  • Cancer1
Leading researchers3
  • Chang AE1
  • Karnell LH1
  • Menck HR1
Affiliations (unnormalised)1
  • University of Michigan Medical Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).

Identifiers
MeSHLentigo
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.