Locked-In Syndrome
Recent clinical, regulatory, research and industry developments relating to this disease.
Implantable Neural Speech Decoders: Recent Advances, Future Challenges.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- Active recent publication activity.
Research HighlightsViewHide
- 2025-09-17Implantable Neural Speech Decoders: Recent Advances, Future Challenges.Jhilal S · 2026
- 2025-09-17ResearchImplantable Neural Speech Decoders: Recent Advances, Future Challenges.Jhilal S · 2026
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Brain-Computer Interfaces3
- Amyotrophic Lateral Sclerosis1
- Anxiety1
- Caregivers1
- Communication Devices for People with Disabilities1
- Locked-In Syndrome1
- Motivation1
- Patient Preference1
Leading journals2
- Neurorehabilitation and neural repair2
- Annals of medicine1
Leading researchers8
- Aarnoutse EJ1
- Branco MP1
- Giraud AL1
- Hattori N1
- He X1
- Hida E1
- Hirata M1
- Jhilal S1
Affiliations (unnormalised)6
- Global Center for Medical Engineering and Informatics1
- Hendaye hospital1
- Institut Pasteur1
- Kyoto Prefectural University of Medicine1
- Lariboisière Hospital1
- Leiden University1
Reference
Authoritative identity, definition & identifiers.
Acquired neuromuscular disorder characterized by complete paralysis of voluntary muscles and lower CRANIAL NERVES except for limited voluntary eye movements. It is due to various cerebrospinal disconnections at or near the PONS and the POSTERIOR CRANIAL FOSSA, typically secondary to pontine hemorrhage or infarct. Because cognitive function is intact it is sometimes referred to as a pseudocoma state.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.