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Disease
Low Back Pain
Late-stage therapeutic developmentEmerging research
2
Publications
24
Clinical trials
2025
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Research2025-06-01Pain practice : the official journal of World Institute of Pain
Multifidus dysfunction and restorative neurostimulation: a scoping review.
Research2023-12-01Pain medicine (Malden, Mass.)
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 6 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
- Q1 2027The Efficacy of Ultrasound-guided Bilateral Superficial Cervical Plexus Block on Postoperative Pain Relief in Patients Undergoing Neck Surgeries, Prospective Randomized Controlled Study.
- Q3 2027Fficacy and Safety of Crisugabalin on Nociplastic Pain in Patients With Parkinson's Disease (RELIEF-PD): A Multicentre, Double-Blind, Randomised Controlled Trial
- Q4 2027A Randomized, Triple-blind, Placebo-controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Intravenous AMBTX-01 (Neridronate) for Treatment of Complex Regional Pain Syndrome Type 1 (CRPS-RISE)
- Q1 2028A Double-Blind, Placebo-Controlled, Randomized Withdrawal Study to Assess the Efficacy and Safety of AXS-14 in the Management of Fibromyalgia
- Q1 2028Does the Perioperative Administration of Dexamethasone Increase the Incidence of Chronic Postmastectomy Pain? A Double-blind Randomized Controlled Trial
Major developments
Upcoming trial readoutHigh impact
Results expected Q1 20282026-07-24
Upcoming trial readoutHigh impact
Results expected Q4 20272026-07-10
Clinical MilestonesView all 16Hide
Results expected
- 2026-07-24A Double-Blind, Placebo-Controlled, Randomized Withdrawal Study to Assess the Efficacy and Safety of AXS-14 in the Management of FibromyalgiaResults expected Q1 2028
- 2026-07-10A Randomized, Triple-blind, Placebo-controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Intravenous AMBTX-01 (Neridronate) for Treatment of Complex Regional Pain Syndrome Type 1 (CRPS-RISE)Results expected Q4 2027
- 2026-06-04Does the Perioperative Administration of Dexamethasone Increase the Incidence of Chronic Postmastectomy Pain? A Double-blind Randomized Controlled TrialResults expected Q1 2028
- 2026-04-23The Efficacy of Ultrasound-guided Bilateral Superficial Cervical Plexus Block on Postoperative Pain Relief in Patients Undergoing Neck Surgeries, Prospective Randomized Controlled Study.Results expected Q1 2027
- 2026-03-19Fficacy and Safety of Crisugabalin on Nociplastic Pain in Patients With Parkinson's Disease (RELIEF-PD): A Multicentre, Double-Blind, Randomised Controlled TrialResults expected Q3 2027
Recently completed
- 2026-06-19Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty: A Blinded Randomized Controlled TrialCompleted
- 2026-03-01Evaluation of the Efficacy of Different Drugs Nebulized at the Glottis on Postoperative Sore Throat in Thyroid Surgery With Nerve Monitoring: a Randomized Controlled TrialCompleted
- 2026-02-18PARASTOP - Paracetamol With Strong Opioids. A Randomized, Double-blind, Parallel-group Non-inferiority Phase III Withdrawal Trial of Paracetamol Versus Placebo in Conjunction With Opioids for Moderate to Severe Cancer-related PainCompleted
- 2026-02-01Ketamine As Adjuvant to Bupivacaine in Ultrasound Guided Quadratus Lumborum Block for Infants Undergoing Open PyeloplastyCompleted
- 2025-12-25Ultrasound-Guided Stellate Ganglion Block in Fibromyalgia: A Randomized, Single-Center, Single-Blind, Sham-Controlled TrialCompleted
Other updates
- 2027-05-30Effect of Dexmedetomidine Combined With Oseltamivir Fumarate for Patient-controlled Intravenous Analgesia Following Lobectomy in Patients With Nicotine DependenceWithdrawn
- 2026-06-01Epidural Steroid Injection With Supplemental Oral Eplerenone for Low Back Pain: A Prospective, Double Blind Randomized TrialWithdrawn
- 2025-12-01Assess the Efficacy of Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant PatientsWithdrawn
- 2025-12-01The Effect of Liposomal Bupivacaine Plus Bupivacaine Versus Bupivacaine Alone on Postoperative Opioid Use After Elective Cesarean Delivery: a Randomized Control TrialWithdrawn
+8 more in the activity timeline below
Activity timeline16
- 2027-05-30ClinicalEffect of Dexmedetomidine Combined With Oseltamivir Fumarate for Patient-controlled Intravenous Analgesia Following Lobectomy in Patients With Nicotine DependenceWithdrawn
- 2026-07-24ClinicalA Double-Blind, Placebo-Controlled, Randomized Withdrawal Study to Assess the Efficacy and Safety of AXS-14 in the Management of FibromyalgiaResults expected Q1 2028
- 2026-07-10ClinicalA Randomized, Triple-blind, Placebo-controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Intravenous AMBTX-01 (Neridronate) for Treatment of Complex Regional Pain Syndrome Type 1 (CRPS-RISE)Results expected Q4 2027
- 2026-06-19ClinicalMultiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty: A Blinded Randomized Controlled TrialCompleted
- 2026-06-04ClinicalDoes the Perioperative Administration of Dexamethasone Increase the Incidence of Chronic Postmastectomy Pain? A Double-blind Randomized Controlled TrialResults expected Q1 2028
- 2026-06-01ClinicalEpidural Steroid Injection With Supplemental Oral Eplerenone for Low Back Pain: A Prospective, Double Blind Randomized TrialWithdrawn
- 2026-04-23ClinicalThe Efficacy of Ultrasound-guided Bilateral Superficial Cervical Plexus Block on Postoperative Pain Relief in Patients Undergoing Neck Surgeries, Prospective Randomized Controlled Study.Results expected Q1 2027
- 2026-03-19ClinicalFficacy and Safety of Crisugabalin on Nociplastic Pain in Patients With Parkinson's Disease (RELIEF-PD): A Multicentre, Double-Blind, Randomised Controlled TrialResults expected Q3 2027
- 2026-03-04ClinicalRandomized Clinical Trial to Evaluate the Efficacy and Safety of Platelet-Rich Plasma (PRP) Injection Combined With Physical Exercise in Chronic OmalgiaResults expected Q1 2029
- 2026-03-01ClinicalEvaluation of the Efficacy of Different Drugs Nebulized at the Glottis on Postoperative Sore Throat in Thyroid Surgery With Nerve Monitoring: a Randomized Controlled TrialCompleted
Clinical trials
The current development programme across all trial phases.
Clinical programme
24
6
18
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Publications over time
20232025
Most influential
Major themes3
- Low Back Pain2
- Paraspinal Muscles2
- Chronic Pain1
Leading journals2
- Pain medicine (Malden, Mass.)1
- Pain practice : the official journal of World Institute of Pain1
Leading researchers8
- Abd-Elsayed A1
- Carayannopoulos AG1
- Hasoon J1
- Kollenburg L1
- Kurt E1
- Sayed D1
- Storlie NR1
- Tieppo Francio V1
Affiliations (unnormalised)6
- Cantor Spine Institute at the Paley Orthopedic & Spine Institute1
- Creighton University School of Medicine1
- Radboud University Medical Center1
- The University of Kansas Medical Center1
- The University of Texas1
- University of Wisconsin School of Medicine and Public Health1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.