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Disease

Mental Fatigue

Late-stage therapeutic developmentEmerging research
MeSHMental Fatigue
1
Publications
5
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones (1 completed or reporting results).
Clinical Milestones1View
Recently completed 1
Activity timeline1

Clinical trials

5 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
5
All trials
0
Active
2
Late-stage
5
Completed
Recently completed

Effect of Transcutaneous Auricular Neurostimulation on Mental Wellness and Resiliency for First Responders: A Pilot Trial

N/A · Completed · Spark Biomedical, Inc.

Do the Effects of Mental Fatigue on Reaction Time and Game Performance in Esport Players Change With Motor Imagery?

N/A · Completed · Bandırma Onyedi Eylül University

Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism

Phase 4 · Completed · Insel Gruppe AG, University Hospital Bern

Effects Of A Proprietary Supplement On The Acute Responses In Reaction Time, Mental Performance, And Indicators Of Focus In Athletic Populations

N/A · Completed · University of Mary Hardin-Baylor

A 28 Day, Randomised, Double-blind, Placebo-controlled, Single-centre Trial to Evaluate the Efficacy and Safety of Pharmaton® PHL 00749 Film Coated Tablets (G115 40 mg, Multivitamin, Multimineral + Guarana 75 mg) 1/Day p.o. in Improving Mental Performance and to Decrease Fatigue in Healthy Male and Female Subjects in Regular Employment.

Phase 3 · Completed · Boehringer Ingelheim

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes2
  • Cognitive Dysfunction1
  • COVID-191
Leading journals1
  • Nature neuroscience1
Leading researchers8
  • Argue R1
  • Brennan D1
  • Campbell M1
  • Cheallaigh CN1
  • Conlon N1
  • Connolly E1
  • Connolly R1
  • Doherty CP1
Affiliations (unnormalised)6
  • Biomedical Sciences Institute1
  • Clinical Research Facility1
  • Health Care Centre1
  • School of Medicine1
  • Science Foundation Ireland Research Centre for Chronic and Rare Neurological Diseases1
  • Smurfit Institute of Genetics1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition of low alertness or cognitive impairment, usually associated with prolonged mental activities or stress.

Identifiers
MeSHMental Fatigue
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.