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Disease

Metaplasia

Late-stage therapeutic developmentEmerging research
MeSHMetaplasia
1
Publications
16
Clinical trials
2019
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones3View
Results posted 1
Results expected 2
Activity timeline3

Clinical trials

10 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
16
All trials
4
Active
4
Late-stage
6
Completed
Recently completed

Metformin Efficacy and Safety for Gastric Intestinal Metaplasia: a Randomized Controlled Trial

Phase 4 · Completed · Xijing Hospital of Digestive Diseases

Targeted Chemoprevention of Gastric Carcinogenesis in High Risk Populations

Phase 2 · Completed · Vanderbilt-Ingram Cancer Center

Therapy of Myeloid Metaplasia-Myelofibrosis, Atypical Chronic Myeloid or Myelomonocytic Leukemia, C-Kit Positive Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (AML-MDS), Hypereosinophilic Syndrome, Polycythemia Vera, and Mastocytosis With Dasatinib (BMS-354825)

Phase 2 · Completed · M.D. Anderson Cancer Center

A Phase 2, Prospective, Randomized, Multicenter, Double-blind, Active-control, Parallel-group Study to Determine the Safety of and to Select a Treatment Regimen of CC-4047 (Pomalidomide) Either as Single-agent or in Combination With Prednisone to Study Further in Subjects With Myelofibrosis With Myeloid Metaplasia

Phase 2 · Completed · Celgene

A Prospective Multicentre Phase II Trial of Zoledronic Acid in Patients With Myelofibrosis With Myeloid Metaplasia (MMM)

Phase 2 · Completed · Universitaire Ziekenhuizen KU Leuven

Ph I/II Study of PTK 787 (Vatalanib) and Gleevec (Imatinib) in Patients With Refractory Acute Myelogenous Leukemia (AML), Agnogenic Myeloid Metaplasia (AMM), and Chronic Myelogenous Leukemia- Blastic Phase (CML-BP)

Phase 1/2 · Completed · M.D. Anderson Cancer Center

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes5
  • Gastritis, Atrophic1
  • Helicobacter Infections1
  • Patient Care Management1
  • Precancerous Conditions1
  • Stomach Neoplasms1
Leading journals1
  • Endoscopy1
Leading researchers8
  • Annibale B1
  • Areia M1
  • Barros R1
  • Carneiro F1
  • Dinis-Ribeiro M1
  • Dumonceau JM1
  • Esposito G1
  • Fléjou JF1
Affiliations (unnormalised)6
  • Center for Research in Health Technologies and Information Systems (CINTESIS)1
  • Centro Hospitalar de São João and Faculty of Medicine1
  • Erasmus MC University Medical Center1
  • Faculté de Médecine Sorbonne Université1
  • Faculty of Medicine of the University of Porto1
  • Gedyt Endoscopy Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition in which there is a change of one adult cell type to another similar adult cell type.

Identifiers
MeSHMetaplasia
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.