Disease

Monosomy

Active therapeutic pipelineEmerging research

MeSHMonosomy

Publications

Clinical trials

2017

Latest publication

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Research2017-08-01Cancer cell

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

1 clinical trial expected to report results, the earliest in Q4 2027.

Upcoming Milestones

Q4 2027Phase II, Open-Label, Prospective Study of T Cell Receptor Alpha/Beta Depletion (A/B TCD) Peripheral Blood Stem Cell (PBSC) Transplantation for Children and Adults With Hematological Malignancies

Major developments

Upcoming trial readoutImportant

Phase II, Open-Label, Prospective Study of T Cell Receptor Alpha/Beta Depletion (A/B TCD) Peripheral Blood Stem Cell (PBSC) Transplantation for Children and Adults With Hematological Malignancies

Results expected Q4 20272026-04-06

Clinical Milestones1View

Results expected 1

2026-04-06Phase II, Open-Label, Prospective Study of T Cell Receptor Alpha/Beta Depletion (A/B TCD) Peripheral Blood Stem Cell (PBSC) Transplantation for Children and Adults With Hematological MalignanciesResults expected Q4 2027

Activity timeline1

2026-04-06ClinicalPhase II, Open-Label, Prospective Study of T Cell Receptor Alpha/Beta Depletion (A/B TCD) Peripheral Blood Stem Cell (PBSC) Transplantation for Children and Adults With Hematological MalignanciesResults expected Q4 2027

Clinical trials

1 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Recruiting

Phase II, Open-Label, Prospective Study of T Cell Receptor Alpha/Beta Depletion (A/B TCD) Peripheral Blood Stem Cell (PBSC) Transplantation for Children and Adults With Hematological Malignancies

Phase 2 · Recruiting · Masonic Cancer Center, University of Minnesota

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Cancer cell · 2017 · 694 cites

Recent publications

Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.

Cancer cell · 2017 · 694 cites

Major themes3

DNA Methylation1
Gene Expression Regulation, Neoplastic1
Mutation1

Leading journals1

Cancer cell1

Leading researchers8

Abdel-Rahman MH1
Akbani R1
Babur O1
Benz C1
Bristow CA1
Cebulla CM1
Chang MT1
Cherniack AD1

Affiliations (unnormalised)6

Buck Institute for Research on Aging1
Canada's Michael Smith Genome Sciences Centre1
Center for Biomolecular Sciences and Engineering1
Center for Cancer Genomics1
Department of Molecular & Clinical Cancer Medicine1
Harvard Medical School1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

The condition in which one chromosome of a pair is missing. In a normally diploid cell it is represented symbolically as 2N-1.

Identifiers

MeSHMonosomy

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.