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Disease

Muscle Spasticity

Late-stage therapeutic developmentEmerging research
MeSHMuscle Spasticity
2
Publications
15
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2029.
Upcoming Milestones
Major developments
Major clinical milestoneImportant
Peripheral Modulation of Muscle Stiffness and Spasticity
Primary completion2026-06-26
Upcoming trial readoutWorth watching
The Effectiveness of Spasticity-correcting Upper Limb Surgery Versus Botulinum Toxin Injections in Patients With Upper Limb Spasticity: an Experimental Study With Paired Design
Results expected Q1 20292025-09-17
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
15
All trials
3
Active
9
Late-stage
6
Completed
Late-stage studies

Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.

Phase 4 · Completed · University Hospital, Toulouse

Intrathecal (IT) Baclofen Drug Distribution Pilot Study

Phase 4 · Completed · Vanderbilt University

A Randomized, Double-blind, Active Drug Controlled, Multi-Center, Phase I/III Clinical Trial to Evaluate the Efficacy and Safety of CORETOX® in Treatment of Post Stroke Upper Limb Spasticity

Phase 3 · Completed · Medy-Tox

A Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Incobotulinumtoxin Type A for the Functional Improvement of Lower Extremity Spasticity in Patients With Multiple Sclerosis

Phase 4 · Completed · Multiple Sclerosis Center of Northeastern New York

Impact of Injection Techniques on the Effectiveness of Botulinum Toxin for the Treatment of Post Stroke Upper Limb Spasticity

Phase 4 · Completed · Medy-Tox

BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity

Phase 3 · Completed · Allergan
Recently completed

Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.

Phase 4 · Completed · University Hospital, Toulouse

Intrathecal (IT) Baclofen Drug Distribution Pilot Study

Phase 4 · Completed · Vanderbilt University

A Randomized, Double-blind, Active Drug Controlled, Multi-Center, Phase I/III Clinical Trial to Evaluate the Efficacy and Safety of CORETOX® in Treatment of Post Stroke Upper Limb Spasticity

Phase 3 · Completed · Medy-Tox

Impact of Injection Techniques on the Effectiveness of Botulinum Toxin for the Treatment of Post Stroke Upper Limb Spasticity

Phase 4 · Completed · Medy-Tox

A Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Incobotulinumtoxin Type A for the Functional Improvement of Lower Extremity Spasticity in Patients With Multiple Sclerosis

Phase 4 · Completed · Multiple Sclerosis Center of Northeastern New York

BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity

Phase 3 · Completed · Allergan

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20152024
Most influential

Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.

JAMA · 2015 · 1,366 cites

Therapeutic use of medical Cannabis in neurological diseases: a clinical update.

Journal of neural transmission (Vienna, Austria : 1996) · 2024 · 9 cites
Recent publications

Therapeutic use of medical Cannabis in neurological diseases: a clinical update.

Journal of neural transmission (Vienna, Austria : 1996) · 2024 · 9 cites

Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.

JAMA · 2015 · 1,366 cites
Major themes3
  • Epilepsy1
  • Medical Marijuana1
  • Multiple Sclerosis1
Leading journals2
  • JAMA1
  • Journal of neural transmission (Vienna, Austria : 1996)1
Leading researchers8
  • Buhmann C1
  • Deshpande S1
  • Di Nisio M1
  • Duffy S1
  • Hernandez AV1
  • Hidding U1
  • Keurentjes JC1
  • Kleijnen J1
Affiliations (unnormalised)6
  • Berlin Institute of Health at Charité-BIH Biomedical Innovation Academy1
  • Institut für Epidemiologie und kongenitale Erkrankungen1
  • Medical School1
  • Radboud University Medical Center1
  • School of Social and Community Medicine1
  • United Kingdom10School for Public Health and Primary Care (CAPHRI)1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)

Identifiers
MeSHMuscle Spasticity
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.