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Disease

Muscle Weakness

Late-stage therapeutic developmentEmerging research
MeSHMuscle Weakness
2
Publications
12
Clinical trials
2021
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Major developments
Major clinical milestoneHigh impact
TESTO-TRIAL: Randomized Clinical Trial on the Use of Testosterone in Critically Ill Patients
Primary completion2026-08-02
Upcoming trial readoutImportant
A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases
Results expected Q1 20272026-02-25
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
12
All trials
3
Active
9
Late-stage
6
Completed
Late-stage studies

Effect of Depo-Medrol Application on the Psoas Muscle After Transpsoas LLIF on Post-operative Hip Flexor Weakness, Thigh Pain and Numbness

Phase 4 · Recruiting · Hardeep Singh

TESTO-TRIAL: Randomized Clinical Trial on the Use of Testosterone in Critically Ill Patients

Phase 4 · Active, not recruiting · Leticia Maria Defendi Barboza Marson

Effect of PROGRESSive Resistance Training, Protein Supplements and Testosterone in Older Frail Men With Testosterone Deficiency (PROGRESS Trial)

Phase 2/3 · Completed · University Hospital, Gentofte, Copenhagen

Evaluation of Effectiveness of Combining High Protein Intake With Early Physical Exercise During Critical Illness to Maintain Muscle Mass in Intensive Care Unite Patient.

Phase 4 · Completed · Tanta University

A Prospective Analysis of Preoperative Fascia Iliaca Block for Hip Arthroscopy

Phase 4 · Completed · University of California, San Francisco

Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training

Phase 3 · Completed · University of Chile
Recently completed

Evaluation of Effectiveness of Combining High Protein Intake With Early Physical Exercise During Critical Illness to Maintain Muscle Mass in Intensive Care Unite Patient.

Phase 4 · Completed · Tanta University

Effect of PROGRESSive Resistance Training, Protein Supplements and Testosterone in Older Frail Men With Testosterone Deficiency (PROGRESS Trial)

Phase 2/3 · Completed · University Hospital, Gentofte, Copenhagen

A Prospective Analysis of Preoperative Fascia Iliaca Block for Hip Arthroscopy

Phase 4 · Completed · University of California, San Francisco

Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training

Phase 3 · Completed · University of Chile

Phase 3 Study of Vitamin D Analog (Alfacalcidol) on Muscle Strength in Elderly Indonesian Women Who Have Low Handgrip Strength

Phase 3 · Completed · Indonesia University

A Randomized, Double-blind, Placebo-controlled, Crossover Study to Evaluate the Efficacy of Coenzyme Q10 in Improving Mitochondrial Function in Older Athletes Treated With Statin Medications

Phase 4 · Completed · Richard Deichmann, MD

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20092021
Major themes1
  • Survivors1
Leading journals2
  • JAMA network open1
  • The Cochrane database of systematic reviews1
Leading researchers8
  • Ba DM1
  • Chinchilli VM1
  • Ericson JE1
  • Groff D1
  • Latham NK1
  • Lekoubou A1
  • Liu CJ1
  • Oh JS1
Affiliations (unnormalised)5
  • Center for Neural Engineering1
  • Indiana University at Indianapolis1
  • Mary Mackillop Institute for Health Research1
  • Penn State College of Medicine and Milton S. Hershey Medical Center1
  • School of Psychology1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)

Identifiers
MeSHMuscle Weakness
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.