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Disease

Muscular Diseases

Late-stage therapeutic developmentEmerging research
MeSHMuscular Diseases
3
Publications
10
Clinical trials
2024
Latest publication
Current focus
Therapeutic developmentInflammation & immunityMetabolic & lifestyle factors
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones3View
Results posted 1
Results expected 1
Recently completed 1
Activity timeline3

Clinical trials

8 sponsors · 0 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
10
All trials
2
Active
7
Late-stage
5
Completed
Late-stage studies

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating the Efficacy and Safety of Human Allogeneic Cardiosphere-Derived Cells for the Treatment of Duchenne Muscular Dystrophy

Phase 3 · Active, not recruiting · Capricor Inc.

Investigations on Differences in Atorvastatin Metabolite Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity

Phase 4 · Completed · Oslo University Hospital

A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Tablets Taken Daily at Bedtime in Patients With Fibromyalgia

Phase 3 · Completed · Tonix Pharmaceuticals, Inc.

A Phase 3, Randomized, Double-blind, Placebo-controlled Efficacy and Safety Study of Ataluren in Patients With Nonsense Mutation Duchenne Muscular Dystrophy and Open-Label Extension

Phase 3 · Completed · PTC Therapeutics

Testosterone Replacement for Older Men With Sarcopenia

Phase 4 · Terminated · Boston Medical Center

A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study To Evaluate The EFFIcacy and Safety of TNX-102 SL Tablets Taken Daily At Bedtime In Patients With FibRoMyalgia

Phase 3 · Terminated · Tonix Pharmaceuticals, Inc.
Recently completed

A Phase 2 Extension Study to Evaluate the Long-Term Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of AOC 1001 Administered Intravenously to Adult Myotonic Dystrophy Type 1 (DM1) Patients

Phase 2 · Completed · Avidity Biosciences, Inc.

A Phase 3, Randomized, Double-blind, Placebo-controlled Efficacy and Safety Study of Ataluren in Patients With Nonsense Mutation Duchenne Muscular Dystrophy and Open-Label Extension

Phase 3 · Completed · PTC Therapeutics

An Open-Label Pilot Study of Pioglitazone in Sporadic Inclusion Body Myositis

Phase 1 · Completed · Johns Hopkins University

A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Tablets Taken Daily at Bedtime in Patients With Fibromyalgia

Phase 3 · Completed · Tonix Pharmaceuticals, Inc.

Investigations on Differences in Atorvastatin Metabolite Ratios as a Diagnostic Tool in Detecting Atorvastatin Induced Myotoxicity

Phase 4 · Completed · Oslo University Hospital

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20202024
Major themes7
  • Muscular Diseases3
  • Gastrointestinal Microbiome1
  • Immune Checkpoint Inhibitors1
  • Immunotherapy1
  • Models, Biological1
  • Muscle, Skeletal1
  • Neoplasms1
Leading journals3
  • Nature communications1
  • Neurology1
  • Wiley interdisciplinary reviews. Systems biology and medicine1
Leading researchers8
  • Akdag G1
  • Baleanu AF1
  • Beecher G1
  • Bowyer RCE1
  • García MP1
  • Greig C1
  • Harridge SDR1
  • Hart D1
Affiliations (unnormalised)6
  • Centre for Human & Applied Physiological Sciences1
  • Clinical Microbiomics1
  • GKT School of Medical Education1
  • King's Clinical Trials Unit1
  • King's College London1
  • MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.

Identifiers
MeSHMuscular Diseases
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.