Disease

Neoplasms, Unknown Primary

Late-stage therapeutic developmentEmerging research

MeSHNeoplasms, Unknown Primary

Publications

Clinical trials

1998

Latest publication

Latest activity

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Recent clinical, regulatory, research and industry developments relating to this disease.

The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society.

Research1998-10-01Cancer

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

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Clinical trials

2 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Late-stage studies

A Randomised Phase III Trial Comparing a Strategy Based on Molecular Analysis to the Empiric Strategy in Patients With Carcinoma of an Unknown Primary (CUP)

Phase 3 · Completed · Gustave Roussy, Cancer Campus, Grand Paris

A Randomized, Phase III Comparison of Gemcitabine/Irinotecan Followed by IRESSA Versus Paclitaxel/Carboplatin/Etoposide Followed by IRESSA in the First-Line Treatment of Patients With Carcinoma of Unknown Primary Site

Phase 3 · Completed · SCRI Development Innovations, LLC

Recently completed

A Randomised Phase III Trial Comparing a Strategy Based on Molecular Analysis to the Empiric Strategy in Patients With Carcinoma of an Unknown Primary (CUP)

Phase 3 · Completed · Gustave Roussy, Cancer Campus, Grand Paris

Phase 3 · Completed · SCRI Development Innovations, LLC

A Phase II Trial of Oxaliplatin and Capecitabine in the Treatment of Patients With Relapsed/Refractory Carcinoma of Unknown Primary Site

Phase 2 · Completed · SCRI Development Innovations, LLC

A Phase II Trial of Bevacizumab and Erlotinib in the Treatment of Patients With Carcinoma of Unknown Primary Site

Phase 2 · Completed · SCRI Development Innovations, LLC

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Cancer · 1998 · 1,075 cites

Recent publications

Cancer · 1998 · 1,075 cites

Leading journals1

Cancer1

Leading researchers3

Chang AE1
Karnell LH1
Menck HR1

Affiliations (unnormalised)1

University of Michigan Medical Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Metastases in which the tissue of origin is unknown.

Identifiers

MeSHNeoplasms, Unknown Primary

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.