Neoplastic Cells, Circulating
Recent clinical, regulatory, research and industry developments relating to this disease.
Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.
Natural killer cells: the immune frontline against circulating tumor cells.
Breaking boundaries: role of the brain barriers in metastatic process.
Liquid biopsy in cancer current: status, challenges and future prospects.
The culture and application of circulating tumor cell-derived organoids.
Multi-stage mechanisms of tumor metastasis and therapeutic strategies.
Liquid biopsy in triple-negative breast cancer: unlocking the potential of precision oncology.
Circulating tumor cells: from new biological insights to clinical practice.
Liquid Biopsy in the Clinical Management of Cancers.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Neoplastic Cells, Circulating25
- Neoplasms7
- Biomarkers, Tumor5
- Circulating Tumor DNA5
- Breast Neoplasms4
- Lung Neoplasms3
- Prostatic Neoplasms3
- Bone Neoplasms2
Leading journals6
- Molecular cancer5
- Signal transduction and targeted therapy5
- Cells2
- Clinical chemistry2
- International journal of molecular sciences2
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology2
Leading researchers8
- Doyle GV3
- Hayes DF3
- Miller MC3
- Terstappen LW3
- Alix-Panabières C2
- Allard WJ2
- Budd GT2
- Cristofanilli M2
Affiliations (unnormalised)6
- National Cancer Institute2
- The First Affiliated Hospital of Zhengzhou University2
- Washington University School of Medicine2
- Affiliated Hospital of Xuzhou Medical University1
- All India Institute of Medical Sciences1
- Allina Health Cancer Institute1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Circulating neoplastic cells are tumor cells that have detached from a primary tumor, entered the bloodstream, and are associated with tumors that metastasize. They are discussed in the literature as circulating tumor cells and as part of liquid biopsy approaches for cancer profiling and monitoring.
The supplied grounding does not support a specific cause or aetiology beyond their association with metastasizing tumors. They are described as cells shed from the primary tumor into the blood.
These cells are part of the metastatic cascade, in which tumor cells slough off from the primary lesion, extravasate, and circulate in blood. The literature links their biology to epithelial-to-mesenchymal transition, tumor microenvironment influences, and genetic and epigenetic mechanisms, with interest in their metabolism and immunology as well.
The grounding does not provide specific risk factors for developing circulating neoplastic cells. Their presence is associated with cancers that are metastasizing.
The literature describes detection and analysis of circulating tumor cells as part of liquid biopsy rather than a treatment. Liquid biopsy is used for cancer molecular profiling, diagnosis, prognosis, monitoring of recurrence or treatment response, and assessment of therapeutic resistance, but no specific therapeutic modality is supported in the grounding for this entity.
AI-generated summary grounded in MeSH and 6 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Exfoliate neoplastic cells circulating in the blood and associated with metastasizing tumors.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.