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Disease

Neuritis

Late-stage therapeutic developmentEmerging research
MeSHNeuritis
1
Publications
19
Clinical trials
1
Associated genes
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 5 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones6View
Results expected 5
Recently completed 1
Activity timeline6

Clinical trials

16 sponsors · 2 new · 0 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
19
All trials
6
Active
8
Late-stage
6
Completed
Late-stage studies

A Randomized Controlled, Open-Label, Rater-Blinded Pragmatic Trial, Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

Phase 3 · Recruiting · Mayo Clinic

A Randomized, Double-masked, Placebo-controlled Study Assessing the Efficacy and Safety of Privosegtor (OCS-05) in Patients With Optic Neuritis (ON)

Phase 3 · Recruiting · Oculis

The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study

Phase 3 · Completed · Asan Medical Center

Dalfampridine After Optic Neuritis to Improve Visual Function in Multiple Sclerosis

Phase 2/3 · Completed · Washington University School of Medicine

Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial

Phase 3 · Completed · University Eye Hospital, Freiburg

Recovery of Demyelinating Optic Neuritis After Treatment With Equivalent High Doses of Oral vs. Intravenous Corticosteroids: a Randomized Single Blinded Clinical Trial

Phase 2/3 · Completed · London Health Sciences Centre
Recruiting

A Randomized Controlled, Open-Label, Rater-Blinded Pragmatic Trial, Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

Phase 3 · Recruiting · Mayo Clinic

A Randomized, Double-masked, Placebo-controlled Study Assessing the Efficacy and Safety of Privosegtor (OCS-05) in Patients With Optic Neuritis (ON)

Phase 3 · Recruiting · Oculis

A Randomized, Double-Blind, Parallel-Group, Placebo Controlled Trial to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis

Phase 2 · Recruiting · University of California, San Francisco

A Pilot Randomized Trial of Efgartigimod Alfa for the Treatment of Incident Moderate to Severe Acute Optic Neuritis

Phase 2 · Recruiting · Anastasia Vishnevetsky, MD, MPH

Edaravone in the Treatment of Optic Neuritis

N/A · Recruiting · First Affiliated Hospital of Guangxi Medical University

Dolutegravir Versus Dolutegravir in Combination With Tenofovir for the Treatment of HTLV-1 Infection (DOT-H): an Open-label, Randomized, Controlled Study.

Phase 2 · Recruiting · Carlos Brites
Recently completed

Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial

Phase 3 · Completed · University Eye Hospital, Freiburg

A Multicenter, Follow-Up Study to Assess Long-Term Electrophysiologic and Clinical Outcomes in Subjects Previously Enrolled in Study 215ON201

Phase 2 · Completed · Biogen

Recovery of Demyelinating Optic Neuritis After Treatment With Equivalent High Doses of Oral vs. Intravenous Corticosteroids: a Randomized Single Blinded Clinical Trial

Phase 2/3 · Completed · London Health Sciences Centre

The Efficacy of Steroid Therapy in Vestibular Neuritis Confirmed by Head Impulse Test: Prospective Randomized Controlled Study

Phase 3 · Completed · Asan Medical Center

Dalfampridine After Optic Neuritis to Improve Visual Function in Multiple Sclerosis

Phase 2/3 · Completed · Washington University School of Medicine

A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on the Retinal Nerve Fiber Layer (RNFL) and Visual Function in Patients With a First Episode of Acute Optic Neuritis (AON)

Phase 3 · Completed · Teva Branded Pharmaceutical Products R&D, Inc.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review.

International journal of molecular sciences · 2023 · 205 cites
Recent publications

Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Treatment: A Review.

International journal of molecular sciences · 2023 · 205 cites
Major themes2
  • Alzheimer Disease1
  • Neuritis1
Leading journals1
  • International journal of molecular sciences1
Leading researchers2
  • Herbet M1
  • Twarowski B1
Affiliations (unnormalised)1
  • Medical University of Lublin1

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

NPIPB110.15

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.

Identifiers
MeSHNeuritis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.