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Disease

Neurobehavioral Manifestations

Late-stage therapeutic developmentEmerging research
MeSHNeurobehavioral Manifestations
1
Publications
7
Clinical trials
1998
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q3 2028.
Upcoming Milestones
Major developments
Upcoming trial readoutImportant
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients: CODEX Trial
Results expected Q3 20282025-12-01
Clinical Milestones1View
Results expected 1
Activity timeline1

Clinical trials

6 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
7
All trials
1
Active
4
Late-stage
6
Completed
Recruiting

Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients: CODEX Trial

Phase 4 · Recruiting · Sunnybrook Health Sciences Centre
Recently completed

A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome

Phase 2/3 · Completed · University of California, Davis

Dopaminergic Therapy for Frontotemporal Dementia Patients: an Interventional, Multi-site, Randomized, Double-blind, Placebo-controlled Study on the Efficacy and Safety of RTG Treatment in Patients with Behavioral FTD

Phase 2 · Completed · I.R.C.C.S. Fondazione Santa Lucia

A Double Blind, Placebo Controlled, Fixed-Flexible Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome

Phase 4 · Completed · Maimonides Medical Center

Hyperoxia: An Unrecognized Mechanism for Inducing "Hypoxia-Like" Symptoms

Phase 4 · Completed · Case Western Reserve University

Acute and Residual Effects of Beer VS. Caffeinated Beer On Simulated Driving

Phase 1/2 · Completed · Boston University

Residual Effects of Intoxication on Student Performance

Phase 2 · Completed · Boston University

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes1
  • Models, Neurological1
Leading journals1
  • Schizophrenia bulletin1
Leading researchers3
  • Andreasen NC1
  • O'Leary DS1
  • Paradiso S1
Affiliations (unnormalised)1
  • The University of Iowa College of Medicine1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Signs and symptoms of higher cortical dysfunction caused by organic conditions. These include certain behavioral alterations and impairments of skills involved in the acquisition, processing, and utilization of knowledge or information.

Identifiers
MeSHNeurobehavioral Manifestations
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.