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Disease

Neurocognitive Disorders

Late-stage therapeutic developmentEmerging research
MeSHNeurocognitive Disorders
1
Publications
15
Clinical trials
1
Associated genes
1981
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2027.
  • 1 industry development reported.
Upcoming Milestones
Clinical Milestones6View
Results posted 2
Results expected 3
Recently completed 1
Industry & Market1View
Activity timeline7

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
15
All trials
6
Active
6
Late-stage
6
Completed
Late-stage studies

Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients: CODEX Trial

Phase 4 · Recruiting · Sunnybrook Health Sciences Centre

Global Study to Investigate Safety and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease

Phase 3 · Active, not recruiting · Eli Lilly and Company

Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults With Early Symptomatic Alzheimer's Disease

Phase 3 · Active, not recruiting · Eli Lilly and Company

Optimizing Anesthesia to Prevent Postoperative Cognitive and Functional Decline in Older Adults: A Randomized Controlled Trial

Phase 4 · Recruiting · Oregon Health and Science University

A Randomised Controlled Clinical Trial of the Efficacy of HAART Intensification With Maraviroc in HIV Virally Suppressed Patients With Cognitive Impairment

Phase 4 · Completed · Bruce Brew

A Randomised Controlled Clinical Trial of the Efficacy of HAART Intensification With Raltegravir in HIV Virally Suppressed Patients With Cognitive Impairment

Phase 4 · Terminated · St Vincent's Hospital, Sydney
Recently completed

A Randomized, Placebo-Controlled, Double-Blind Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation

Phase 2 · Completed · Inmune Bio, Inc.

Dopaminergic Therapy for Frontotemporal Dementia Patients: an Interventional, Multi-site, Randomized, Double-blind, Placebo-controlled Study on the Efficacy and Safety of RTG Treatment in Patients with Behavioral FTD

Phase 2 · Completed · I.R.C.C.S. Fondazione Santa Lucia

Characterization of Neuroimmune Dysfunction in Alcohol Use Disorder

Phase 1 · Completed · University of Maryland, Baltimore

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, and Efficacy of NA-831 in Alzheimer Patients With Mild Cognitive Impairment

Phase 2 · Completed · Biomed Industries, Inc.

Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness

Phase 2 · Completed · Géraldine Martens

A Randomised Controlled Clinical Trial of the Efficacy of HAART Intensification With Maraviroc in HIV Virally Suppressed Patients With Cognitive Impairment

Phase 4 · Completed · Bruce Brew

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Infantile autism reviewed: a decade of research.

Schizophrenia bulletin · 1981 · 146 cites
Recent publications

Infantile autism reviewed: a decade of research.

Schizophrenia bulletin · 1981 · 146 cites
Leading journals1
  • Schizophrenia bulletin1
Leading researchers3
  • DeMyer MK1
  • Hingtgen JN1
  • Jackson RK1

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

APLP20.08

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Diagnoses of DEMENTIA and AMNESTIC DISORDER are subsumed here. (DSM-5)

Identifiers
MeSHNeurocognitive Disorders
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.