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Disease

Neurocognitive Disorders

Late-stage therapeutic developmentEmerging research
MeSHNeurocognitive Disorders
1
Publications
15
Clinical trials
1981
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Infantile autism reviewed: a decade of research.

Research1981-01-01Schizophrenia bulletin

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Clinical Milestones6View
Results posted 2
Results expected 3
Recently completed 1
Activity timeline6

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
15
All trials
6
Active
6
Late-stage
6
Completed
Late-stage studies

Optimizing Anesthesia to Prevent Postoperative Cognitive and Functional Decline in Older Adults: A Randomized Controlled Trial

Phase 4 · Recruiting · Oregon Health and Science University

Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients: CODEX Trial

Phase 4 · Recruiting · Sunnybrook Health Sciences Centre

Global Study to Investigate Safety and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease

Phase 3 · Active, not recruiting · Eli Lilly and Company

Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults With Early Symptomatic Alzheimer's Disease

Phase 3 · Active, not recruiting · Eli Lilly and Company

A Randomised Controlled Clinical Trial of the Efficacy of HAART Intensification With Maraviroc in HIV Virally Suppressed Patients With Cognitive Impairment

Phase 4 · Completed · Bruce Brew

A Randomised Controlled Clinical Trial of the Efficacy of HAART Intensification With Raltegravir in HIV Virally Suppressed Patients With Cognitive Impairment

Phase 4 · Terminated · St Vincent's Hospital, Sydney
Recently completed

A Randomized, Placebo-Controlled, Double-Blind Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation

Phase 2 · Completed · Inmune Bio, Inc.

Dopaminergic Therapy for Frontotemporal Dementia Patients: an Interventional, Multi-site, Randomized, Double-blind, Placebo-controlled Study on the Efficacy and Safety of RTG Treatment in Patients with Behavioral FTD

Phase 2 · Completed · I.R.C.C.S. Fondazione Santa Lucia

Characterization of Neuroimmune Dysfunction in Alcohol Use Disorder

Phase 1 · Completed · University of Maryland, Baltimore

A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, and Efficacy of NA-831 in Alzheimer Patients With Mild Cognitive Impairment

Phase 2 · Completed · Biomed Industries, Inc.

Long Term Effects of Soft Splints on Stroke Patients and Patients With Disorders of Consciousness

Phase 2 · Completed · Géraldine Martens

A Randomised Controlled Clinical Trial of the Efficacy of HAART Intensification With Maraviroc in HIV Virally Suppressed Patients With Cognitive Impairment

Phase 4 · Completed · Bruce Brew

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Infantile autism reviewed: a decade of research.

Schizophrenia bulletin · 1981 · 146 cites
Recent publications

Infantile autism reviewed: a decade of research.

Schizophrenia bulletin · 1981 · 146 cites
Leading journals1
  • Schizophrenia bulletin1
Leading researchers3
  • DeMyer MK1
  • Hingtgen JN1
  • Jackson RK1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Diagnoses of DEMENTIA and AMNESTIC DISORDER are subsumed here. (DSM-5)

Identifiers
MeSHNeurocognitive Disorders
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.