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Disease

Neurodevelopmental disorder with seizures and non-epileptic hyperkinetic movements

Late-stage therapeutic development
22
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q1 2029.
Upcoming Milestones
Major developments
Major trial resultsHigh impact
CPT-SMART for Treatment of PTSD and Cigarette Smoking
Results posted2026-07-02
Upcoming trial readoutHigh impact
CELESTE: Comparative Effectiveness Study of behavioraL and Drug-rElated inSomnia Therapies for pEri- and Post-menopausal People
Results expected Q1 20312026-06-08
Clinical Milestones7View
Results posted 2
Results expected 3
Recently completed 2
Activity timeline7

Clinical trials

18 sponsors · 2 new · 2 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
22
All trials
6
Active
17
Late-stage
6
Completed
Late-stage studies

CELESTE: Comparative Effectiveness Study of behavioraL and Drug-rElated inSomnia Therapies for pEri- and Post-menopausal People

Phase 4 · Recruiting · Brigham and Women's Hospital

Mechanistic Clinical Trial Evaluating the Role of the Metabotropic Glutamate Receptor Subtype 5 (mGluR5) in the Antidepressant Mechanism of Cognitive Behavioral Therapy for Insomnia (CBT-I)

Phase 4 · Recruiting · Stony Brook University

Partners in Caring for Anxious Youth

Phase 3 · Active, not recruiting · Ann & Robert H Lurie Children's Hospital of Chicago

Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving Rapid Eye Movement Behavior Disorder with Parkinson's Disease

Phase 4 · Recruiting · Beijing Friendship Hospital

Personalized Indications for Cognitive Behavioural Therapy and Antidepressants in the Treatment of Major Depressive Disorder and Persistent Depressive Disorder

Phase 4 · Recruiting · Nova Scotia Health Authority

The Effects of Solriamfetol and CBT-I (Alone and in Combination) on Sleep Continuity, Sleepiness, Fatigue, and Performance in Patients With Insomnia Disorder

Phase 4 · Completed · University of Pennsylvania
Recruiting

CELESTE: Comparative Effectiveness Study of behavioraL and Drug-rElated inSomnia Therapies for pEri- and Post-menopausal People

Phase 4 · Recruiting · Brigham and Women's Hospital

Mechanistic Clinical Trial Evaluating the Role of the Metabotropic Glutamate Receptor Subtype 5 (mGluR5) in the Antidepressant Mechanism of Cognitive Behavioral Therapy for Insomnia (CBT-I)

Phase 4 · Recruiting · Stony Brook University

Multimodal Image Technologies Investigate the Role and Mechanism of Probiotics in Improving Rapid Eye Movement Behavior Disorder with Parkinson's Disease

Phase 4 · Recruiting · Beijing Friendship Hospital

Personalized Indications for Cognitive Behavioural Therapy and Antidepressants in the Treatment of Major Depressive Disorder and Persistent Depressive Disorder

Phase 4 · Recruiting · Nova Scotia Health Authority

Repurposing Semaglutide for the Treatment of Cocaine Use Disorder: a Pilot Mechanistic Study

Phase 2 · Recruiting · The University of Texas Health Science Center, Houston
Recently completed

The Effects of Solriamfetol and CBT-I (Alone and in Combination) on Sleep Continuity, Sleepiness, Fatigue, and Performance in Patients With Insomnia Disorder

Phase 4 · Completed · University of Pennsylvania

CPT-SMART for Treatment of PTSD and Cigarette Smoking

Phase 4 · Completed · VA Office of Research and Development

Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial

Phase 4 · Completed · Unity Health Toronto

Pain Response Evaluation of a Combined Intervention to Cope Effectively (PRECICE)

Phase 4 · Completed · Wake Forest University Health Sciences

Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patients With Post-COVID Asthenic Syndrome

Phase 4 · Completed · Promomed, LLC

A Randomized Controlled Trial of Telephone-delivered Cognitive Behavioral-therapy, Modafinil, and Combination Therapy of Both Interventions for Fatigue in Multiple Sclerosis

Phase 4 · Completed · University of Michigan

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

CACNA1B0.70

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Voltage-dependent N-type calcium channel subunit alpha-1Bvia CACNA1B0.70
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.