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Disease

Onchocerciasis

Late-stage therapeutic developmentEmerging research
MeSHOnchocerciasis
1
Publications
14
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Control, elimination, and eradication efforts for neglected tropical diseases in the World Health Organization African region over the last 30 years: A scoping review.

Research2024-01-22International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2029.
Upcoming Milestones
Major developments
Major trial resultsHigh impact
A Randomized, Double Blind, Parallel Group Clinical Trial to Evaluate the Safety of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Treatment With Albendazole
Results posted2026-03-03
Major clinical milestoneImportant
A Phase-II, Randomised, Double-blind, Parallel-group Trial to Investigate Emodepside (BAY 44-4400) in Subjects With Onchocerca Volvulus Infection, Comprising: Part 1 to Investigate Safety, Tolerability, Pharmacodynamics, Pharmacokinetics and Dose-Response Relationship for Efficacy (Proof-of-Concept); Part 2 to Investigate Efficacy of Selected Doses, Safety, Tolerability and Pharmacokinetics
Primary completion2026-09-18
Clinical Milestones5View
Results posted 1
Results expected 1
Recently completed 3
Activity timeline5

Clinical trials

11 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
14
All trials
5
Active
6
Late-stage
6
Completed
Late-stage studies

Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases: A Cluster-randomised Trial

Phase 4 · Recruiting · Kirby Institute

A Randomized, Double Blind, Parallel Trial in the Democratic Republic of Congo (DRC) Comparing the Safety and Efficacy of Annual or Biannual Doses of Moxidectin or Ivermectin for Treatment of Onchocerciasis

Phase 3 · Active, not recruiting · Medicines Development for Global Health

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy: A Randomized Clinical Trial

Phase 4 · Completed · Robert Colebunders

Comparison of Ivermectin Alone With Albendazole (ALB) Plus Ivermectin (IVM) in Their Efficacy Against Onchocerciasis in the Volta Region, Ghana.

Phase 3 · Completed · University Hospitals Cleveland Medical Center

Comparison of Ivermectin Alone With Albendazole (ALB) Plus Ivermectin (IVM) in Their Efficacy Against Onchocerciasis

Phase 3 · Completed · University Hospitals Cleveland Medical Center

A Randomized, Double Blind, Parallel Group Clinical Trial to Evaluate the Safety of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Treatment With Albendazole

Phase 3 · Completed · Medicines Development for Global Health
Recently completed

A Randomized, Double Blind, Parallel Group Clinical Trial to Evaluate the Safety of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Treatment With Albendazole

Phase 3 · Completed · Medicines Development for Global Health

Randomized Clinical Trial, Double-blind, Single-dose Drug and Escalating Infection Intensities, Evaluating the Safety and Efficacy of Moxidectin 2 mg, Ivermectin-controlled, in Loa Loa Microfilaremic Patients

Phase 2 · Completed · Center for Research on Filariasis and Other Tropical Diseases, Cameroon

Safety and Efficacy of Combination Therapy With Ivermectin, Diethylcarbamazine, and Albendazole (IDA) for Individuals With Onchocerciasis

Phase 2 · Completed · Washington University School of Medicine

Comparison of Ivermectin Alone With Albendazole (ALB) Plus Ivermectin (IVM) in Their Efficacy Against Onchocerciasis in the Volta Region, Ghana.

Phase 3 · Completed · University Hospitals Cleveland Medical Center

Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy: A Randomized Clinical Trial

Phase 4 · Completed · Robert Colebunders

Comparison of Ivermectin Alone With Albendazole (ALB) Plus Ivermectin (IVM) in Their Efficacy Against Onchocerciasis

Phase 3 · Completed · University Hospitals Cleveland Medical Center

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Control, elimination, and eradication efforts for neglected tropical diseases in the World Health Organization African region over the last 30 years: A scoping review.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024 · 12 cites
Recent publications

Control, elimination, and eradication efforts for neglected tropical diseases in the World Health Organization African region over the last 30 years: A scoping review.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024 · 12 cites
Major themes4
  • Disease Eradication1
  • Neglected Diseases1
  • Tropical Medicine1
  • World Health Organization1
Leading journals1
  • International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases1
Leading researchers8
  • Achu D1
  • Barry A1
  • Campos A1
  • Farham B1
  • Impouma B1
  • Juma E1
  • Kalu A1
  • Wolfe CM1
Affiliations (unnormalised)1
  • Congo; University of South Florida College of Public Health1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Infection with nematodes of the genus ONCHOCERCA. Characteristics include the presence of firm subcutaneous nodules filled with adult worms, PRURITUS, and ocular lesions.

Identifiers
MeSHOnchocerciasis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.