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Disease

Opportunistic Infections

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHOpportunistic Infections
4
Publications
8
Clinical trials
2024
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q3 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutWorth watching
Antigen Specific Adoptive T Cell Therapy for Opportunistic Cytomegalovirus Infection Occurring After Stem Cell Transplant
Results expected Q3 20272025-10-22
Clinical Milestones1View
Results expected 1
Activity timeline1

Clinical trials

7 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
8
All trials
1
Active
5
Late-stage
5
Completed
Late-stage studies

A Phase IV Study of Antiretroviral Therapy for HIV Infected Adults Presenting With Acute Opportunistic Infections: Immediate Versus Deferred Initiation of Antiretroviral Therapy

Phase 4 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

A Phase II Prospective Randomized Trial of Donor T-memory Cells (CD45RA Depleted) Infusion for Prevention of Infections After Allogeneic TcRαβ/CD19-depleted Hematopoietic Stem Cell Transplantation

Phase 2/3 · Completed · Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria

Phase 4 · Completed · University of Bergen

An Evaluation of the Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on the Development of Antifolate Resistance Among Plasmodium Falciparum, Streptococcus Pneumoniae, and Escherichia Coli

Phase 4 · Completed · Centers for Disease Control and Prevention

Cryptococcal Antigen Screening Plus Sertraline

Phase 3 · Terminated · University of Minnesota
Recently completed

A Phase II Prospective Randomized Trial of Donor T-memory Cells (CD45RA Depleted) Infusion for Prevention of Infections After Allogeneic TcRαβ/CD19-depleted Hematopoietic Stem Cell Transplantation

Phase 2/3 · Completed · Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria

Phase 4 · Completed · University of Bergen

Transfusion of CD45RA-depleted Donor Lymphocytes to Improve Regeneration of Antimicrobial Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation

Phase 1/2 · Completed · Federal Research Institute of Pediatric Hematology, Oncology and Immunology

A Phase IV Study of Antiretroviral Therapy for HIV Infected Adults Presenting With Acute Opportunistic Infections: Immediate Versus Deferred Initiation of Antiretroviral Therapy

Phase 4 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

An Evaluation of the Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on the Development of Antifolate Resistance Among Plasmodium Falciparum, Streptococcus Pneumoniae, and Escherichia Coli

Phase 4 · Completed · Centers for Disease Control and Prevention

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20172024
Major themes7
  • Biofilms1
  • Infection Control1
  • Population Surveillance1
  • Proctocolectomy, Restorative1
  • Staphylococcal Infections1
  • Staphylococcus epidermidis1
  • Virulence Factors1
Leading journals4
  • Frontiers in immunology1
  • Journal of Crohn's & colitis1
  • Nature medicine1
  • Virulence1
Leading researchers8
  • Ang B1
  • Ardizzone S1
  • Armuzzi A1
  • Av-Shalom TV1
  • Barreiro-de Acosta M1
  • Bell SC1
  • Bertrand D1
  • Burisch J1
Affiliations (unnormalised)6
  • Centre for Molecular Therapeutics1
  • Centre for Tropical Bioinformatics and Molecular Biology1
  • Chaim Sheba Medical Center1
  • Department of Laboratory Medicine1
  • Duke-NUS Graduate Medical School1
  • Fondazione Policlinico Universitario Gemelli Universita' Cattolica del Sacro Cuore1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Identifiers
MeSHOpportunistic Infections
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.