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Disease

Opportunistic Infections

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHOpportunistic Infections
4
Publications
9
Clinical trials
2024
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

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Clinical trials

8 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
9
All trials
1
Active
5
Late-stage
6
Completed
Late-stage studies

A Phase IV Study of Antiretroviral Therapy for HIV Infected Adults Presenting With Acute Opportunistic Infections: Immediate Versus Deferred Initiation of Antiretroviral Therapy

Phase 4 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

A Phase II Prospective Randomized Trial of Donor T-memory Cells (CD45RA Depleted) Infusion for Prevention of Infections After Allogeneic TcRαβ/CD19-depleted Hematopoietic Stem Cell Transplantation

Phase 2/3 · Completed · Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria

Phase 4 · Completed · University of Bergen

An Evaluation of the Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on the Development of Antifolate Resistance Among Plasmodium Falciparum, Streptococcus Pneumoniae, and Escherichia Coli

Phase 4 · Completed · Centers for Disease Control and Prevention

Cryptococcal Antigen Screening Plus Sertraline

Phase 3 · Terminated · University of Minnesota
Recently completed

Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs)

N/A · Completed · St George's, University of London

A Phase II Prospective Randomized Trial of Donor T-memory Cells (CD45RA Depleted) Infusion for Prevention of Infections After Allogeneic TcRαβ/CD19-depleted Hematopoietic Stem Cell Transplantation

Phase 2/3 · Completed · Federal Research Institute of Pediatric Hematology, Oncology and Immunology

Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria

Phase 4 · Completed · University of Bergen

Transfusion of CD45RA-depleted Donor Lymphocytes to Improve Regeneration of Antimicrobial Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation

Phase 1/2 · Completed · Federal Research Institute of Pediatric Hematology, Oncology and Immunology

A Phase IV Study of Antiretroviral Therapy for HIV Infected Adults Presenting With Acute Opportunistic Infections: Immediate Versus Deferred Initiation of Antiretroviral Therapy

Phase 4 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

An Evaluation of the Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on the Development of Antifolate Resistance Among Plasmodium Falciparum, Streptococcus Pneumoniae, and Escherichia Coli

Phase 4 · Completed · Centers for Disease Control and Prevention

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
2017–2024
Major themes7
  • Biofilms1
  • Infection Control1
  • Population Surveillance1
  • Proctocolectomy, Restorative1
  • Staphylococcal Infections1
  • Staphylococcus epidermidis1
  • Virulence Factors1
Leading journals4
  • Frontiers in immunology1
  • Journal of Crohn's & colitis1
  • Nature medicine1
  • Virulence1
Leading researchers8
  • Ang B1
  • Ardizzone S1
  • Armuzzi A1
  • Av-Shalom TV1
  • Barreiro-de Acosta M1
  • Bell SC1
  • Bertrand D1
  • Burisch J1
Affiliations (unnormalised)6
  • Centre for Molecular Therapeutics1
  • Centre for Tropical Bioinformatics and Molecular Biology1
  • Chaim Sheba Medical Center1
  • Department of Laboratory Medicine1
  • Duke-NUS Graduate Medical School1
  • Fondazione Policlinico Universitario Gemelli Universita' Cattolica del Sacro Cuore1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Identifiers
MeSHOpportunistic Infections
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.