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Disease

Otitis Media

Late-stage therapeutic developmentEmerging research
MeSHOtitis Media
2
Publications
16
Clinical trials
2025
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q2 2027.
Upcoming Milestones
Clinical Milestones4View
Results expected 2
Recently completed 2
Activity timeline4

Clinical trials

14 sponsors · 2 new · 1 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
16
All trials
3
Active
13
Late-stage
6
Completed
Late-stage studies

Effect of Saccharomyces Boulardii CNCM I-745 on Antibiotic-perturbed Microbiota in Children: RESTORE STUDY

Phase 4 · Active, not recruiting · Eskisehir Osmangazi University

A Study of V114 and Acute Otitis Media in Children (PNEU-ERA)

Phase 3 · Completed · Merck Sharp & Dohme LLC

Otological Safety Profile of 100% Manuka Honey Application in Tympanoplasty: A Double-blinded Randomized Controlled Trial

Phase 2/3 · Completed · Fakultas Kedokteran Universitas Indonesia

A Multicenter, Open-label, Non-comparative Phase IV Clinical Study to Evaluate the Safety and Clinical Efficacy of Augmentin Extra Strength (ES)-600 in Children With Acute Otitis Media (AOM) in India

Phase 4 · Completed · GlaxoSmithKline

Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children: A Randomized Controlled Trial

Phase 4 · Completed · University of Oulu

Phase III, Multicenter, Randomized, Double-Blind, Placebo- Controlled Parallel-Designed Evaluation to Assess Safety and Efficacy of Topical Benzocaine for Treatment of Pain Associated With Acute Otitis Media in Children Ages 5 to 12 Years

Phase 3 · Completed · Lachlan Pharma Holdings
Recently completed

A Study of V114 and Acute Otitis Media in Children (PNEU-ERA)

Phase 3 · Completed · Merck Sharp & Dohme LLC

A Multicenter, Open-label, Non-comparative Phase IV Clinical Study to Evaluate the Safety and Clinical Efficacy of Augmentin Extra Strength (ES)-600 in Children With Acute Otitis Media (AOM) in India

Phase 4 · Completed · GlaxoSmithKline

Otological Safety Profile of 100% Manuka Honey Application in Tympanoplasty: A Double-blinded Randomized Controlled Trial

Phase 2/3 · Completed · Fakultas Kedokteran Universitas Indonesia

Effects of 100% Medical Grade Manuka Honey on Re-epithelialization Post Tympanoplasty in the Case of Mucosal Type Chronic Suppurative Otitis Media (CSOM) - A Prospective Double-blinded Randomized Controlled Trial

Phase 2/3 · Completed · Fakultas Kedokteran Universitas Indonesia

Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children: A Randomized Controlled Trial

Phase 4 · Completed · University of Oulu

Phase III, Multicenter, Randomized, Double-Blind, Placebo- Controlled Parallel-Designed Evaluation to Assess Safety and Efficacy of Topical Benzocaine for Treatment of Pain Associated With Acute Otitis Media in Children Ages 5 to 12 Years

Phase 3 · Completed · Lachlan Pharma Holdings

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20132025
Major themes5
  • Biofilms1
  • Global Burden of Disease1
  • Otitis Media1
  • Respiratory Tract Infections1
  • Water Microbiology1
Leading journals2
  • APMIS. Supplementum1
  • The Lancet. Infectious diseases1
Leading researchers1
  • Bjarnsholt T1
Affiliations (unnormalised)1
  • Københavns Universitet1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.

Identifiers
MeSHOtitis Media
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.