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Disease

Ovarian neoplasm

Late-stage therapeutic development
Also known as neoplasm of ovary, neoplasm of the ovary, ovarian tumor, ovarian tumors+10 more

neoplasm of ovary, neoplasm of the ovary, ovarian tumor, ovarian tumors, ovarian tumour, ovarian tumours, ovary neoplasm, ovary neoplasm (disease), ovary tumor, ovary tumour, tumor of ovary, tumor of the ovary, tumour of ovary, tumour of the ovary.

16
Clinical trials
12
Associated genes
9
Related proteins
Current focus
Mono-adp-ribosyltransferase parp3 biologyMucin-16 biologyTherapeutic development

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones3View
Results expected 1
Recently completed 2
Activity timeline3

Clinical trials

13 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
16
All trials
5
Active
3
Late-stage
6
Completed
Late-stage studies

MAintenance Therapy With Aromatase Inhibitor in Epithelial Ovarian Cancer: a Randomized Double-blinded Placebo-controlled Multi-centre Phase III Trial (ENGOT-ov54/Swiss-GO-2/MATAO), Including LOGOS (Low Grade Ovarian Cancer Sub-study).

Phase 3 · Recruiting · Swiss GO Trial Group

A Phase 3 Study of Relacorilant in Combination With Nab-Paclitaxel Versus Nab-Paclitaxel Monotherapy in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer (ROSELLA)

Phase 3 · Active, not recruiting · Corcept Therapeutics

A Phase 3 Placebo-Controlled Study of Carboplatin/Paclitaxel With or Without Concurrent and Continuation Maintenance Veliparib (PARP Inhibitor) in Subjects With Previously Untreated Stages III or IV High-Grade Serous Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 3 · Terminated · AbbVie
Recently completed

Cohort A: PARP Inhibitor-Naïve Platinum-Resistant Ovarian Cancer Treatment Cohort With TSR-042, Bevacizumab, and Niraparib

Phase 2 · Completed · Tesaro, Inc.

A Phase II Study of Sorafenib and Bevacizumab in Epithelial Ovarian, Fallopian, and Peritoneal Cancer

Phase 2 · Completed · National Cancer Institute (NCI)

A Phase II Non-randomized Study of DOXIL Consolidation Treatment for Ovarian Cancer, Cancer of the Fallopian Tube or Peritoneal Carcinoma.

Phase 2 · Completed · Southeastern Gynecologic Oncology

A Phase II Open-label, Non-comparative, International, Multicentre Study to Assess the Efficacy and Safety of KU 0059436 Given Orally Twice Daily in Patients With Advanced BRCA1 or BRCA2 Associated Ovarian Cancer

Phase 2 · Completed · AstraZeneca

A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin With G-CSF for Patients With Newly Diagnosed Advanced Stage Ovarian Cancer

Phase 2 · Completed · National Cancer Institute (NCI)

CT-2103/Carboplatin for Patients With Newly Diagnosed Stage III or IV Ovarian or Primary Peritoneal Cancer: A Phase 2 Study

Phase 2 · Completed · CTI BioPharma

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

PARP10.51PARP20.50PARP30.46NTRK30.41OGFRL10.41TENM30.39LARGE10.39MUC160.38FOLR10.38SLA0.38PTPRN20.37FNDC10.37

Disease biology

9 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Poly [ADP-ribose] polymerase 1via PARP10.51Poly [ADP-ribose] polymerase 2via PARP20.50Protein mono-ADP-ribosyltransferase PARP3via PARP30.46NT-3 growth factor receptorvia NTRK30.41Mucin-16via MUC160.38Folate receptor alphavia FOLR10.38Rabphilin-3Avia RPH3A0.29Sialoadhesinvia SIGLEC10.28Annexin A2via ANXA20.27

Reference

Authoritative identity, definition & identifiers.

Synonyms

neoplasm of ovary, neoplasm of the ovary, ovarian tumor, ovarian tumors, ovarian tumour, ovarian tumours, ovary neoplasm, ovary neoplasm (disease), ovary tumor, ovary tumour, tumor of ovary, tumor of the ovary, tumour of ovary, tumour of the ovary

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.