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Disease

Paralysis

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHParalysis
3
Publications
12
Clinical trials
1
Related conditions
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q2 2030.
Upcoming Milestones
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

12 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
12
All trials
2
Active
6
Late-stage
6
Completed
Late-stage studies

Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function Evaluated With Diaphragm Thickening Fraction

Phase 4 · Completed · Bozyaka Training and Research Hospital

Diaphragmatic Paralysis After Interscalene Brachial Plexus Block: A Randomized, Double-blinded, Unicenter and Controlled Clinical Trial to Reduce the Dose of Levobupivacaine 0,25% 20 ml to 10 ml Undergoing Arthroscopic Shoulder Surgery

Phase 3 · Completed · Instituto de Investigación Sanitaria Aragón

Dichlorphenamide vs. Placebo for Periodic Paralysis

Phase 3 · Completed · University of Rochester

The Early Reversibility of Rocuronium After Different Doses of Neostigmine

Phase 4 · Completed · National Institutes of Health Clinical Center (CC)

Interscalene Block and Dysfunction Diaphragmatic: Effect of Low Volume of Ropivacaine 0,1%. A Randomised, Controlled Trial

Phase 3 · Completed · University Hospital, Lille

Evaluation of Diaphragm Movement After an Interscalene Block

Phase 4 · Completed · University of Minnesota
Recruiting

MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System

N/A · Recruiting · Nader Pouratian
Recently completed

Diaphragmatic Paralysis After Interscalene Brachial Plexus Block: A Randomized, Double-blinded, Unicenter and Controlled Clinical Trial to Reduce the Dose of Levobupivacaine 0,25% 20 ml to 10 ml Undergoing Arthroscopic Shoulder Surgery

Phase 3 · Completed · Instituto de Investigación Sanitaria Aragón

Comparison of Different Approaches for Supraclavicular Block and Their Effects on Diaphragm Muscle Function Evaluated With Diaphragm Thickening Fraction

Phase 4 · Completed · Bozyaka Training and Research Hospital

Interscalene Block and Dysfunction Diaphragmatic: Effect of Low Volume of Ropivacaine 0,1%. A Randomised, Controlled Trial

Phase 3 · Completed · University Hospital, Lille

Evaluation of Diaphragm Movement After an Interscalene Block

Phase 4 · Completed · University of Minnesota

Dichlorphenamide vs. Placebo for Periodic Paralysis

Phase 3 · Completed · University of Rochester

The Early Reversibility of Rocuronium After Different Doses of Neostigmine

Phase 4 · Completed · National Institutes of Health Clinical Center (CC)

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20212024
Major themes6
  • Brain-Computer Interfaces3
  • Amyotrophic Lateral Sclerosis1
  • Neural Prostheses1
  • Neurosciences1
  • Paralysis1
  • Speech1
Leading journals3
  • Journal of neural engineering1
  • Nature1
  • The Journal of physiology1
Leading researchers8
  • Antonietti A1
  • Avansino DT1
  • Birbaumer N1
  • Chaudhary U1
  • Choi EY1
  • Druckmann S1
  • Fan C1
  • French J1
Affiliations (unnormalised)6
  • Carnegie Mellon University1
  • Center for Neurotechnology and Neurorecovery1
  • Howard Hughes Medical Institute at Stanford University1
  • Institute of Medical Psychology and Behavioral Neurobiology1
  • Loyola University1
  • Massachusetts General Hospital and Harvard Medical School1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Amyotrophic Lateral Sclerosis2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)

Identifiers
MeSHParalysis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.