Disease

Penile Neoplasms

Active therapeutic pipelineEmerging research

MeSHPenile Neoplasms

Publications

Clinical trials

Related conditions

2023

Latest publication

Latest activity

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Recent clinical, regulatory, research and industry developments relating to this disease.

Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors.

Research2023-12-01Journal of the National Cancer Institute

Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers.

Research2023-08-11Cancer

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

1 clinical trial with recent milestones.

Major developments

Major clinical milestoneImportant

Phase II Basket Study to Evaluate the Tissue-agnostic Efficacy of Anti-Programmed Cell Death Protein 1 (Anti-PD1) Monoclonal Antibody in Patients With Advanced Rare Tumors

Primary completion2026-07-01

Clinical Milestones1View

Recently completed 1

2026-07-01Phase II Basket Study to Evaluate the Tissue-agnostic Efficacy of Anti-Programmed Cell Death Protein 1 (Anti-PD1) Monoclonal Antibody in Patients With Advanced Rare TumorsPrimary completion

Activity timeline1

2026-07-01ClinicalPhase II Basket Study to Evaluate the Tissue-agnostic Efficacy of Anti-Programmed Cell Death Protein 1 (Anti-PD1) Monoclonal Antibody in Patients With Advanced Rare TumorsPrimary completion

Clinical trials

5 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Recruiting

Phase II Basket Study to Evaluate the Tissue-agnostic Efficacy of Anti-Programmed Cell Death Protein 1 (Anti-PD1) Monoclonal Antibody in Patients With Advanced Rare Tumors

Phase 2 · Recruiting · Instituto do Cancer do Estado de São Paulo

Recently completed

Therapeutic HPV Vaccine (BNT113) Trial in HPV16 Driven Carcinoma

Phase 1/2 · Completed · University of Southampton

Secured Access to Nivolumab for Adult Patients With Selected Rare Cancer Types

Phase 2 · Completed · UNICANCER

A Phase II Trial of Vinflunine Chemotherapy in Locally-advanced and Metastatic Carcinoma of the Penis

Phase 2 · Completed · Institute of Cancer Research, United Kingdom

Phase II Study of the Pan-HER Inhibitor Dacomitinib (PF-00299804) for Patients With Locally Advanced or Metastatic Squamous Cell Carcinoma of the Penis.

Phase 2 · Completed · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors.

Journal of the National Cancer Institute · 2023 · 44 cites

Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers.

Cancer · 2023 · 36 cites

Recent publications

Safety and efficacy of immune checkpoint inhibitors in advanced penile cancer: report from the Global Society of Rare Genitourinary Tumors.

Journal of the National Cancer Institute · 2023 · 44 cites

Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers.

Cancer · 2023 · 36 cites

Major themes4

Carcinoma, Squamous Cell2
Penile Neoplasms2
Antineoplastic Agents, Immunological1
Papillomavirus Infections1

Leading journals2

Cancer1
Journal of the National Cancer Institute1

Leading researchers8

McKay RR2
Nazha B2
Abdel-Wahab N1
Adra N1
Antonuzzo L1
Apolo AB1
Appleman L1
Barata P1

Affiliations (unnormalised)6

Emory University School of Medicine2
University Hospitals Seidman Cancer Center2
University of California San Diego2
Advent Health Cancer Institute1
Assiut University Faculty of Medicine1
Center for Cancer Research1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Carcinoma, Squamous Cell2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Cancers or tumors of the PENIS or of its component tissues.

Identifiers

MeSHPenile Neoplasms

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.