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Disease

Peri-Implantitis

Late-stage therapeutic developmentEmerging researchSteady momentum
MeSHPeri-Implantitis
4
Publications
16
Clinical trials
2
Related conditions
2025
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Clinical trial2026-07-22Status changed to Completed · ClinicalTrials.gov

Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic.

Research2025-02-11Frontiers in cellular and infection microbiology

Role of immune dysregulation in peri-implantitis.

Research2024-11-01Frontiers in immunology

Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline.

Research2023-06-04Journal of clinical periodontology

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones4View
Results expected 3
Recently completed 1
Activity timeline4

Clinical trials

14 sponsors · 2 new · 0 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
16
All trials
6
Active
7
Late-stage
6
Completed
Late-stage studies

Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial

Phase 4 · Recruiting · University of Milan

Demonstration of OTC Naproxen Sodium's (Aleve's) Anti-inflammatory Action in Dental Implant Surgery Patients

Phase 4 · Completed · Hersh, Elliot V., DMD, MS, PhD

Clinical Evaluation of Topical Melatonin Application on Implant Stability of Immediate Dental Implant in Anterior & Premolar Region in Systemically Healthy Patients (Randomized Clinical Trial)

Phase 4 · Completed · Cairo University

Reconstructive Therapy of Advanced Peri-implantitis-related Bone Defect with PDGF-BB (Gem-21)

Phase 4 · Completed · Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain

Survival Rate of Dental Implants Placed in Sinus Lift Performed With Two Different Grafts

Phase 4 · Completed · Grupo de Investigação: Cirurgia Oral, Peridontologia, Implantologia

The Evaluation of Enamel Matrix Derivative on the Bone Regenerative Potential of the Dental Implant With Transcrestal Sinus Lifting Technique: Randomized-Controlled CBCT Study

Phase 4 · Completed · T.C. Dumlupınar Üniversitesi
Recruiting

Immediate Versus Delayed Loading of Single Posterior Zirconia Implants: A Multicenter Randomized Controlled Clinical Trial

Phase 4 · Recruiting · University of Milan

Comparison of Biofilm Accumulation on the Surface of Zirconia Versus Titanium Implants. Randomized Controlled Pilot Clinical Trial

N/A · Recruiting · Universidad Complutense de Madrid

Comparison of Two-piece Zirconia Implants With Tissue-level and Bone-level Platform: Randomized Controlled Clinical Trial

N/A · Recruiting · University of Ljubljana

Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental Implants Using the Polymerase Chain Reaction Method

N/A · Recruiting · University of Zagreb

Assessment of Soft Tissue Thickness Following Utilization of Buccal Pad of Fat Versus Platelet-rich Fibrin for Covering Zygomatic Implants: A Randomized Clinical Trial

N/A · Recruiting · Cairo University

Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis: A Post-Marketing Interventional Pilot Study With a Medical Device

N/A · Recruiting · Koite Health Oy
Recently completed

Reconstructive Therapy of Advanced Peri-implantitis-related Bone Defect with PDGF-BB (Gem-21)

Phase 4 · Completed · Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain

Demonstration of OTC Naproxen Sodium's (Aleve's) Anti-inflammatory Action in Dental Implant Surgery Patients

Phase 4 · Completed · Hersh, Elliot V., DMD, MS, PhD

Clinical Evaluation of Topical Melatonin Application on Implant Stability of Immediate Dental Implant in Anterior & Premolar Region in Systemically Healthy Patients (Randomized Clinical Trial)

Phase 4 · Completed · Cairo University

Pilot Study: The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Peri-implant Mucositis

Phase 4 · Completed · Rowpar Pharmaceuticals, Inc.

The Evaluation of Enamel Matrix Derivative on the Bone Regenerative Potential of the Dental Implant With Transcrestal Sinus Lifting Technique: Randomized-Controlled CBCT Study

Phase 4 · Completed · T.C. Dumlupınar Üniversitesi

Survival Rate of Dental Implants Placed in Sinus Lift Performed With Two Different Grafts

Phase 4 · Completed · Grupo de Investigação: Cirurgia Oral, Peridontologia, Implantologia

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20232025
Major themes7
  • Peri-Implantitis4
  • Periodontitis2
  • Communicable Diseases1
  • Dental Implants1
  • Dysbiosis1
  • Mucositis1
  • Tooth1
Leading journals4
  • Frontiers in cellular and infection microbiology1
  • Frontiers in immunology1
  • Journal of applied microbiology1
  • Journal of clinical periodontology1
Leading researchers8
  • Barão VAR1
  • Berglundh T1
  • Bertolini M1
  • Chapple I1
  • Costa RC1
  • Cui Z1
  • de Avila ÉD1
  • Dini C1
Affiliations (unnormalised)6
  • School of Dental Medicine2
  • Birmingham Community Healthcare NHS Foundation Trust1
  • Center of Oral Implantology1
  • College of Dental Medicine1
  • Guarulhos University1
  • Harvard School of Dental Medicine1

Related conditions

2 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Dysbiosis2Periodontitis2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An inflammatory process with loss of supporting bone in the tissues surrounding functioning DENTAL IMPLANTS.

Identifiers
MeSHPeri-Implantitis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.