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Disease
Peri-Implantitis
Late-stage therapeutic developmentEmerging researchSteady momentum
4
Publications
16
Clinical trials
2
Related conditions
1
Associated genes
2025
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Antiseptic Effects on the Dental Implant Internal Surface Microbiome
Clinical trial2026-07-22Status changed to Completed · ClinicalTrials.gov
Research2025-02-11Frontiers in cellular and infection microbiology
Role of immune dysregulation in peri-implantitis.
Research2024-11-01Frontiers in immunology
Prevention and treatment of peri-implant diseases-The EFP S3 level clinical practice guideline.
Research2023-06-04Journal of clinical periodontology
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 3 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
- Q1 2027Immediate Versus Delayed Surgical Reconstruction of Peri-implantitis Intra-bony Defects: A Parallel-arm, Assessor-blind, Randomized, Controlled Clinical Trial
- Q2 2027Impact of Implantoplasty on Local and Systemic Inflammation in Peri-implantitis: A Randomized Controlled Trial
- Q1 2028Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)
Major developments
Upcoming trial readoutImportant
Results expected Q2 20272026-05-01
Major clinical milestoneImportant
Primary completion2026-08-01
Clinical MilestonesViewHide
Results expected
- 2026-05-01Impact of Implantoplasty on Local and Systemic Inflammation in Peri-implantitis: A Randomized Controlled TrialResults expected Q2 2027
- 2026-03-13Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)Results expected Q1 2028
- 2026-02-06Immediate Versus Delayed Surgical Reconstruction of Peri-implantitis Intra-bony Defects: A Parallel-arm, Assessor-blind, Randomized, Controlled Clinical TrialResults expected Q1 2027
Recently completed
- 2026-08-01Management of Peri-implantitis: Non-surgical Treatment of Peri-implantitis: Mechanical Debridement vs. Air-polishingPrimary completion
- 2026-07-30Efficacy of Photodynamic Therapy in the Non-Surgical Treatment of Peri-ImplantitisPrimary completion
Activity timeline5
- 2026-08-01ClinicalManagement of Peri-implantitis: Non-surgical Treatment of Peri-implantitis: Mechanical Debridement vs. Air-polishingPrimary completion
- 2026-07-30ClinicalEfficacy of Photodynamic Therapy in the Non-Surgical Treatment of Peri-ImplantitisPrimary completion
- 2026-05-01ClinicalImpact of Implantoplasty on Local and Systemic Inflammation in Peri-implantitis: A Randomized Controlled TrialResults expected Q2 2027
- 2026-03-13ClinicalMinimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)Results expected Q1 2028
- 2026-02-06ClinicalImmediate Versus Delayed Surgical Reconstruction of Peri-implantitis Intra-bony Defects: A Parallel-arm, Assessor-blind, Randomized, Controlled Clinical TrialResults expected Q1 2027
Clinical trials
The current development programme across all trial phases.
Clinical programme
16
6
7
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Publications over time
20232025
Most influential
Recent publications
Major themes7
- Peri-Implantitis4
- Periodontitis2
- Communicable Diseases1
- Dental Implants1
- Dysbiosis1
- Mucositis1
- Tooth1
Leading journals4
- Frontiers in cellular and infection microbiology1
- Frontiers in immunology1
- Journal of applied microbiology1
- Journal of clinical periodontology1
Leading researchers8
- Barão VAR1
- Berglundh T1
- Bertolini M1
- Chapple I1
- Costa RC1
- Cui Z1
- de Avila ÉD1
- Dini C1
Affiliations (unnormalised)6
- School of Dental Medicine2
- Birmingham Community Healthcare NHS Foundation Trust1
- Center of Oral Implantology1
- College of Dental Medicine1
- Guarulhos University1
- Harvard School of Dental Medicine1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
An inflammatory process with loss of supporting bone in the tissues surrounding functioning DENTAL IMPLANTS.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.