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Disease

Periapical Periodontitis

Active therapeutic pipelineEmerging research
MeSHPeriapical Periodontitis
1
Publications
6
Clinical trials
2006
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

On the causes of persistent apical periodontitis: a review.

Research2006-04-01International endodontic journal

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones.
Clinical Milestones1View
Recently completed 1
Activity timeline1

Clinical trials

3 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
6
All trials
1
Active
0
Late-stage
4
Completed
Recently completed

Effect of Simvastatin Versus Calcium Hydroxide Used as Intracanal Medicaments on Post-operative Pain and Total Amount of IL-6 and IL-8 in Periapical Fluids in Patients With Symptomatic Apical Periodontitis: A Randomized Clinical Trial

N/A · Completed · Cairo University

Effect of Intracanal Cryotherapy and Metformin on Postoperative Pain in Teeth With Symptomatic Apical Periodontitis: A Randomized Clinical Trial

Phase 2 · Completed · Celalettin Topbaş

Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial.

N/A · Completed · Cairo University

Healing Rates After Single Versus Multiple Visits Endodontic Treatment of Necrotic Teeth With Apical Periodontitis: A Randomized Clinical Trial

Phase 1 · Completed · Cairo University

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

On the causes of persistent apical periodontitis: a review.

International endodontic journal · 2006 · 567 cites
Recent publications

On the causes of persistent apical periodontitis: a review.

International endodontic journal · 2006 · 567 cites
Leading journals1
  • International endodontic journal1
Leading researchers1
  • Nair PN1
Affiliations (unnormalised)1
  • Institute of Oral Biology1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Inflammation of the PERIAPICAL TISSUE. It includes general, unspecified, or acute nonsuppurative inflammation. Chronic nonsuppurative inflammation is PERIAPICAL GRANULOMA. Suppurative inflammation is PERIAPICAL ABSCESS.

Identifiers
MeSHPeriapical Periodontitis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.