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Disease

Poisoning

Late-stage therapeutic development

Also known as Poisonings, intoxication, poisoning syndrome.

16
Clinical trials
12
Associated genes
6
Related proteins
Current focus
Acetylcholinesterase biologyEphrin-b2 biologyTherapeutic development
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q2 2028.
  • 4 industry developments reported.
Upcoming Milestones
Major developments
Upcoming trial readoutImportant
Reduction of Digestive Absorption of Toxic Substances by Combined Digestive Decontamination in Intensive Care - Randomized Single-center Study
Results expected Q2 20282026-07-06
Major clinical milestoneImportant
CHARPP (Activated CHARcoal in Poisoned Patient): RCT Pilot Study
Primary completion2026-06-01
Clinical Milestones4View
Results expected 1
Recently completed 2
Other updates 1
Industry & Market4View
Activity timeline8

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Hydroxocobalaminapproved

Original application approval — Treatment of known or suspected cyanide poisoning. Cyanokit is to be administered togethe… (2007)

Clinical trials

15 sponsors · 2 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
16
All trials
4
Active
11
Late-stage
6
Completed
Late-stage studies

The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning

Phase 4 · Recruiting · China Medical University Hospital

CHARPP (Activated CHARcoal in Poisoned Patient): RCT Pilot Study

Phase 4 · Recruiting · Laval University

Effectiveness of Calcium Channel Blockade for Organophosphorus and Carbamate Pesticide Poisoning - an Open, Pragmatic, 3-arm RCT Repurposing Two Widely Available Licensed Medicines

Phase 3 · Completed · University of Edinburgh

Use of a Weight Loss Aid in a Population Exposed to Polybrominated Biphenyls (PBB)

Phase 4 · Completed · Emory University

Bioretina Inc Ankara University Technopolis

Phase 3 · Completed · Ankara Universitesi Teknokent

Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study

Phase 2/3 · Completed · Instituto Bioclon S.A. de C.V.
Recruiting

The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning

Phase 4 · Recruiting · China Medical University Hospital

CHARPP (Activated CHARcoal in Poisoned Patient): RCT Pilot Study

Phase 4 · Recruiting · Laval University

Reduction of Digestive Absorption of Toxic Substances by Combined Digestive Decontamination in Intensive Care - Randomized Single-center Study

Phase 2 · Recruiting · Assistance Publique - Hôpitaux de Paris

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of a Single Dose of Intravenous CS 1103 Following a Single Intravenous Dose of Fentanyl in Healthy Subjects With Naloxone Blockade

Phase 2 · Recruiting · Clear Scientific, Inc.
Recently completed

Effectiveness of Calcium Channel Blockade for Organophosphorus and Carbamate Pesticide Poisoning - an Open, Pragmatic, 3-arm RCT Repurposing Two Widely Available Licensed Medicines

Phase 3 · Completed · University of Edinburgh

Use of a Weight Loss Aid in a Population Exposed to Polybrominated Biphenyls (PBB)

Phase 4 · Completed · Emory University

Bioretina Inc Ankara University Technopolis

Phase 3 · Completed · Ankara Universitesi Teknokent

Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study

Phase 2/3 · Completed · Instituto Bioclon S.A. de C.V.

Pilot Study - Assessing the Impact of Using a Neuromuscular Blocking Agent to Reduce Neuromuscular Junction Damage and Intermediate Syndrome in Organophosphorus (OP) Insecticide Poisoned Patients Requiring Ventilation

Phase 2/3 · Completed · University of Edinburgh

Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital

Phase 4 · Completed · Assiut University

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

Product approvals and authorisations
2007emaOriginal application approval — Hydroxocobalamin· Treatment of known or suspected cyanide poisoning. Cyanokit is to be administered together with appropriate decontamination and supportive measures. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

ACHE0.51KAZN0.41HS3ST40.40ST180.37DIP2C0.36ATP13A50.35CNTN30.35FSIP20.35KCMF10.34DMAC10.34CCDC910.34DOCK40.33

Disease biology

6 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Acetylcholinesterasevia ACHE0.51Inhibin beta A chainvia INHBA0.32Short transient receptor potential channel 6via TRPC60.31Ephrin-B2via EFNB20.31Histone-lysine N-methyltransferase KMT5Bvia KMT5B0.28Aquaporin-4via AQP40.26

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.

Synonyms

Poisonings, intoxication, poisoning syndrome

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.