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Disease

Poisoning

Late-stage therapeutic development

Also known as Poisonings, intoxication, poisoning syndrome.

16
Clinical trials
12
Associated genes
6
Related proteins
Current focus
Acetylcholinesterase biologyEphrin-b2 biologyTherapeutic development
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

Approval: Cyanokit (EMA)

Regulatory2007-11-23EMA

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q2 2028.
  • 2 industry developments reported.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Reduction of Digestive Absorption of Toxic Substances by Combined Digestive Decontamination in Intensive Care - Randomized Single-center Study
Results expected Q2 20282026-07-06
Major clinical milestoneImportant
CHARPP (Activated CHARcoal in Poisoned Patient): RCT Pilot Study
Primary completion2026-06-01
Clinical Milestones4View
Results expected 1
Recently completed 2
Other updates 1
Industry & Market2View
Activity timeline6

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Hydroxocobalaminapproved

Approval — Treatment of known or suspected cyanide poisoning. Cyanokit is to be administered togethe… (2007)

Clinical trials

15 sponsors · 2 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
16
All trials
4
Active
11
Late-stage
6
Completed
Late-stage studies

The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning

Phase 4 · Recruiting · China Medical University Hospital

CHARPP (Activated CHARcoal in Poisoned Patient): RCT Pilot Study

Phase 4 · Recruiting · Laval University

Effectiveness of Calcium Channel Blockade for Organophosphorus and Carbamate Pesticide Poisoning - an Open, Pragmatic, 3-arm RCT Repurposing Two Widely Available Licensed Medicines

Phase 3 · Completed · University of Edinburgh

Use of a Weight Loss Aid in a Population Exposed to Polybrominated Biphenyls (PBB)

Phase 4 · Completed · Emory University

Bioretina Inc Ankara University Technopolis

Phase 3 · Completed · Ankara Universitesi Teknokent

Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study

Phase 2/3 · Completed · Instituto Bioclon S.A. de C.V.
Recruiting

The Efficacy of Dexamethasone in Combination With N-acetylcysteine in Preventing Neurocognitive Sequelae Due to Carbon Monoxide Poisoning

Phase 4 · Recruiting · China Medical University Hospital

CHARPP (Activated CHARcoal in Poisoned Patient): RCT Pilot Study

Phase 4 · Recruiting · Laval University

Reduction of Digestive Absorption of Toxic Substances by Combined Digestive Decontamination in Intensive Care - Randomized Single-center Study

Phase 2 · Recruiting · Assistance Publique - Hôpitaux de Paris

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of a Single Dose of Intravenous CS 1103 Following a Single Intravenous Dose of Fentanyl in Healthy Subjects With Naloxone Blockade

Phase 2 · Recruiting · Clear Scientific, Inc.
Recently completed

Effectiveness of Calcium Channel Blockade for Organophosphorus and Carbamate Pesticide Poisoning - an Open, Pragmatic, 3-arm RCT Repurposing Two Widely Available Licensed Medicines

Phase 3 · Completed · University of Edinburgh

Use of a Weight Loss Aid in a Population Exposed to Polybrominated Biphenyls (PBB)

Phase 4 · Completed · Emory University

Bioretina Inc Ankara University Technopolis

Phase 3 · Completed · Ankara Universitesi Teknokent

Phase 2/3 Study for Scorpion North Africa Middle East Envenomation With a Immune F(ab')2 (Equine) Antivenom Alacramyn NAMO. A Randomized, Double-Blind, Placebo-controlled, Prospective and Multicenter Study

Phase 2/3 · Completed · Instituto Bioclon S.A. de C.V.

Pilot Study - Assessing the Impact of Using a Neuromuscular Blocking Agent to Reduce Neuromuscular Junction Damage and Intermediate Syndrome in Organophosphorus (OP) Insecticide Poisoned Patients Requiring Ventilation

Phase 2/3 · Completed · University of Edinburgh

Supportive Measures in Treatment of Aluminum Phosphide Poisoning as a Trial to Reduce Mortality at Assiut University Hospital

Phase 4 · Completed · Assiut University

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals
2007emaApproval — Hydroxocobalamin· Treatment of known or suspected cyanide poisoning. Cyanokit is to be administered together with appropriate decontamination and supportive measures. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

ACHE0.51KAZN0.41HS3ST40.40ST180.37DIP2C0.36ATP13A50.35CNTN30.35FSIP20.35KCMF10.34DMAC10.34CCDC910.34DOCK40.33

Disease biology

6 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Acetylcholinesterasevia ACHE0.51Inhibin beta A chainvia INHBA0.32Short transient receptor potential channel 6via TRPC60.31Ephrin-B2via EFNB20.31Histone-lysine N-methyltransferase KMT5Bvia KMT5B0.28Aquaporin-4via AQP40.26

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.

Synonyms

Poisonings, intoxication, poisoning syndrome

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.