Disease

Postoperative Nausea and Vomiting

Late-stage therapeutic developmentEmerging research

MeSHPostoperative Nausea and Vomiting

Publications

Clinical trials

2020

Latest publication

Latest activity

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Recent clinical, regulatory, research and industry developments relating to this disease.

Adding Aprepitant to a Multimodal Strategy for the Prevention of Postoperative Nausea and Vomiting in High-risk Outpatient Surgical Patients

Clinical trial2026-08-27Status changed to Completed · ClinicalTrials.gov

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

2 clinical trials expected to report results, the earliest in Q4 2026.

Upcoming Milestones

Major developments

Upcoming trial readoutImportant

Investigation of the Effects of Two Different TCI (Target Controlled Infusion) Models (Paedfusor and Eleveld) and Inhalation Anesthesia on Postoperative Awakening Agitation/Delirium in Pediatric Patients

Results expected Q4 20272026-04-16

Major clinical milestoneImportant

Pilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic Cholecystectomy

Primary completion2026-03-31

Clinical Milestones5View

Results expected 2

2026-04-16Investigation of the Effects of Two Different TCI (Target Controlled Infusion) Models (Paedfusor and Eleveld) and Inhalation Anesthesia on Postoperative Awakening Agitation/Delirium in Pediatric PatientsResults expected Q4 2027
2026-01-07A Randomized Control Trial on the Efficacy of Aromatherapy in Reducing Postoperative Nausea and Vomiting in Total Joint Replacement PatientsResults expected Q4 2026

Recently completed 3

Activity timeline5

2026-04-16ClinicalInvestigation of the Effects of Two Different TCI (Target Controlled Infusion) Models (Paedfusor and Eleveld) and Inhalation Anesthesia on Postoperative Awakening Agitation/Delirium in Pediatric PatientsResults expected Q4 2027
2026-03-31ClinicalPilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic CholecystectomyPrimary completion
2026-02-28ClinicalA Randomized Clinical Trial; Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients Undergoing Laparoscopic Surgery at a Single Centre in LebanonPrimary completion
2026-01-07ClinicalA Randomized Control Trial on the Efficacy of Aromatherapy in Reducing Postoperative Nausea and Vomiting in Total Joint Replacement PatientsResults expected Q4 2026
2025-12-30ClinicalImpact of Intraoperative Paragastric Block on Visceral Pain and Postoperative Nausea and Vomiting After Sleeve Gastrectomy: A Randomized Controlled TrialPrimary completion

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies

Aprepitantapproved

Approval — Emend 40 mg hard capsules is indicated for the prevention of postoperative nausea and vom… (2003)

Clinical trials

8 sponsors · 3 new · 0 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Late-stage studies

Pilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic Cholecystectomy

Phase 4 · Active, not recruiting · Instituto Mexicano del Seguro Social

The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy: A Randomised Double-blind, Placebo-controlled Trial

Phase 2/3 · Completed · Odense University Hospital

Recruiting

Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

Phase 2 · Recruiting · United States Naval Medical Center, Portsmouth

N/A · Recruiting · Marmara University Pendik Training and Research Hospital

A Randomized Control Trial on the Efficacy of Aromatherapy in Reducing Postoperative Nausea and Vomiting in Total Joint Replacement Patients

N/A · Recruiting · Hong Kong Buddhist Hospital

Impact of Intraoperative Paragastric Block on Visceral Pain and Postoperative Nausea and Vomiting After Sleeve Gastrectomy: A Randomized Controlled Trial

N/A · Recruiting · Umraniye Education and Research Hospital

Recently completed

The Effect of Perioperative Dexamethasone Administration on Postoperative Pain in Patients Undergoing Periacetabular Osteotomy: A Randomised Double-blind, Placebo-controlled Trial

Phase 2/3 · Completed · Odense University Hospital

Zusanli (ST36) Acupoint Injection With Anisodamine for Postoperative Nausea and Vomiting in Women Following Bariatric Surgery: A Single-center Study

N/A · Completed · The Second Hospital of Anhui Medical University

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals

2003emaApproval — Aprepitant· Emend 40 mg hard capsules is indicated for the prevention of postoperative nausea and vomiting (PONV) in adults. Emend is also available as 80 mg and 125 mg hard capsules for the prevention of nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in adults and adolescents from the age of 12 (see separate Summary of Product Characteristics). Emend is also available as 165 mg hard capsules for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin based cancer chemotherapy in adults and the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy in adults. Emend is also available as powder for oral suspension for the prevention of nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in children, toddlers and infants from the age of 6 months to less than 12 years. Emend 80 mg, 125 mg, 165 mg hard capsules and Emend powder for oral suspension are given as part of combination therapy. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS<sup>®</sup>) Society recommendations.

Acta orthopaedica · 2020 · 461 cites

Recent publications

Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS<sup>®</sup>) Society recommendations.

Acta orthopaedica · 2020 · 461 cites

Major themes1

Enhanced Recovery After Surgery1

Leading journals1

Acta orthopaedica1

Leading researchers8

Gill M1
Ljungqvist O1
McDonald DA1
Middleton RG1
Reed M1
Sahota O1
Wainwright TW1
Yates P1

Affiliations (unnormalised)6

Glasgow Caledonian University1
Golden Jubilee National Hospital1
Northumbria Healthcare NHS Foundational Trust1
Nottingham University1
Nottingham University Hospital1
Örebro University1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Emesis and queasiness occurring after anesthesia.

Identifiers

MeSHPostoperative Nausea and Vomiting

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.