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Disease

Postoperative Nausea and Vomiting

Late-stage therapeutic developmentEmerging research
MeSHPostoperative Nausea and Vomiting
1
Publications
23
Clinical trials
2020
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 5 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones11View all 11
Results posted 1
Results expected 5
Recently completed 4
Other updates 1
+3 more in the activity timeline below
Activity timeline11

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Aprepitantapproved

Approval — Emend 40 mg hard capsules is indicated for the prevention of postoperative nausea and vom… (2003)

Clinical trials

17 sponsors · 6 new · 5 completed in the last 12 months (net +6)

The current development programme across all trial phases.

Clinical programme
23
All trials
6
Active
17
Late-stage
5
Completed
Late-stage studies

Electroacupuncture for Managing Chemotherapy-Induced Gastrointestinal Symptom Clusters in Patients With Breast Cancer

Phase 3 · Recruiting · Jiuda Zhao

A Randomized, Dose-Ranging Trial of Propofol-Only and Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

Phase 4 · Recruiting · Boston Children's Hospital

Flex Appeal: A Prospective Randomized Controlled Trial Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia (MUA)

Phase 4 · Recruiting · Duke University

Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Phase 4 · Active, not recruiting · University of Calgary

Comparison of Norepinephrine Versus Phenylephrine Infusion for Prevention of Hypotension Due to Subarachnoid Block in Elderly Patients Undergoing Orthopedic Hip Surgery:A Prospective Randomized Trial

Phase 4 · Recruiting · Sohag University

Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis A Prospective Randomized Double-Blind Controlled Trial

Phase 4 · Recruiting · Nashwa Ahmed
Recruiting

Electroacupuncture for Managing Chemotherapy-Induced Gastrointestinal Symptom Clusters in Patients With Breast Cancer

Phase 3 · Recruiting · Jiuda Zhao

A Randomized, Dose-Ranging Trial of Propofol-Only and Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

Phase 4 · Recruiting · Boston Children's Hospital

Flex Appeal: A Prospective Randomized Controlled Trial Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia (MUA)

Phase 4 · Recruiting · Duke University

Comparison of Norepinephrine Versus Phenylephrine Infusion for Prevention of Hypotension Due to Subarachnoid Block in Elderly Patients Undergoing Orthopedic Hip Surgery:A Prospective Randomized Trial

Phase 4 · Recruiting · Sohag University

Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis A Prospective Randomized Double-Blind Controlled Trial

Phase 4 · Recruiting · Nashwa Ahmed
Recently completed

Does Tranexamic Acid Reduce the Need for Deliberate Hypotensive Anesthesia Within Orthognathic Surgery? A Prospective Study

Phase 4 · Completed · University of Alabama at Birmingham

Comparison of Continuous Norepinephrine and Phenylephrine Infusion for Preventing Hypotension During Low-Dose Spinal Anesthesia in Cesarean Delivery: A Randomized Controlled Trial

Phase 4 · Completed · Tam Anh Research Institute

A Randomized Controlled Trial of Ultrasound Guided Knee Genicular Nerve Block and Anterior Femoral Cutaneous Nerve Block for Primary Total Knee Arthroplasty

Phase 4 · Completed · Hospital for Special Surgery, New York

A Multicenter, Randomized, Double-blind, Double-dummy, Positive-controlled Phase III Trial, to Evaluate the Efficacy and Safety of QLM2010 for Prevention of Chemotherapy-induced Nausea and Vomiting After Highly Emetogenic Chemotherapy

Phase 3 · Completed · Qilu Pharmaceutical Co., Ltd.

Effect of Early Versus Late Aminophylline Administration on Recovery Profile in Pediatric Patients Undergoing Ambulatory Surgery Under General Anesthesia; a Randomised Controlled Trial

Phase 3 · Completed · Hany Mohammed El-Hadi Shoukat Mohammed

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals
2003emaApproval — Aprepitant· Emend 40 mg hard capsules is indicated for the prevention of postoperative nausea and vomiting (PONV) in adults. Emend is also available as 80 mg and 125 mg hard capsules for the prevention of nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in adults and adolescents from the age of 12 (see separate Summary of Product Characteristics). Emend is also available as 165 mg hard capsules for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin based cancer chemotherapy in adults and the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy in adults. Emend is also available as powder for oral suspension for the prevention of nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in children, toddlers and infants from the age of 6 months to less than 12 years. Emend 80 mg, 125 mg, 165 mg hard capsules and Emend powder for oral suspension are given as part of combination therapy. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes1
  • Enhanced Recovery After Surgery1
Leading journals1
  • Acta orthopaedica1
Leading researchers8
  • Gill M1
  • Ljungqvist O1
  • McDonald DA1
  • Middleton RG1
  • Reed M1
  • Sahota O1
  • Wainwright TW1
  • Yates P1
Affiliations (unnormalised)6
  • Glasgow Caledonian University1
  • Golden Jubilee National Hospital1
  • Northumbria Healthcare NHS Foundational Trust1
  • Nottingham University1
  • Nottingham University Hospital1
  • Örebro University1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Emesis and queasiness occurring after anesthesia.

Identifiers
MeSHPostoperative Nausea and Vomiting
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.