Back to discover
Disease

Pregnancy in Obesity

Late-stage therapeutic developmentEmerging research
MeSHPregnancy in Obesity
2
Publications
24
Clinical trials
2025
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Preconception use of GLP-1 and GLP-1/GIP receptor agonists for obesity treatment.

Research2025-09-24Best practice & research. Clinical endocrinology & metabolism

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: High
Key developments
  • 6 clinical trials expected to report results, the earliest in Q2 2027.
  • Active recent publication activity.
Upcoming Milestones
Research Highlights1View
Clinical Milestones18View all 18
Results posted 1
Results expected 5
Recently completed 5
Other updates 5
+10 more in the activity timeline below
Activity timeline19

Clinical trials

12 sponsors · 3 new · 6 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Weight Maintenance in Adolescents With Obesity; Long-Term Treatment With Semaglutide s.c.2.4 mg Once-weekly

Phase 4 · Active, not recruiting · Novo Nordisk A/S

A Phase IV Study to Assess the Effect of Naltrexone Hydrochloride Extended Release (ER) and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on the Occurrence of Major Adverse Cardiovascular Events

Phase 4 · Active, not recruiting · Currax Pharmaceuticals

Effect of Metformin ER With Hypocaloric Diet on Weight Loss in Overweight/Obese Patients With Increased Waist Circumference

Phase 4 · Active, not recruiting · University of California, Los Angeles

A Novel Precision Medicine Approach For Obesity: A Randomized, Multi-Center Trial

Phase 4 · Active, not recruiting · Mayo Clinic

Efficacy, Metabolic and Cardiovascular Effects of Liraglutide in Children Aged 6-12 Years With Severe Obesity: A Randomized Controlled Trial With Advanced Echocardiographic Assessment

Phase 4 · Active, not recruiting · University of Sao Paulo General Hospital

A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants With Hypertension and Obesity or Overweight: Randomized, Double-Blind, Placebo-Controlled Trials (ATTAIN-HYPERTENSION)

Phase 3 · Active, not recruiting · Eli Lilly and Company
Recently completed

Pharmacological and Behavioral Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes After Bariatric Surgery: Maintenance Treatment (Stage 2a)

Phase 2/3 · Completed · Yale University

A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants With Severe Obesity and Established Cardiovascular Disease

Phase 3 · Completed · Eli Lilly and Company

A Master Protocol to Investigate the Efficacy and Safety of LY3437943 Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Overweight: A Randomized, Double-Blind, Placebo-Controlled Trial (TRIUMPH-1)

Phase 3 · Completed · Eli Lilly and Company

A Randomized, Allocation-concealed, Assessor-blinded, Parallel-group Trial Evaluating the Association Between Erectile Dysfunction and Left Ventricular Diastolic Dysfunction and Comparing the Effects of Tadalafil, SGLT2 Inhibitors, and Their Combination in Patients With Metabolic Syndrome.

Phase 4 · Completed · Kafrelsheikh University

Efficacy and Safety of Ixekizumab or Ixekizumab Concomitantly Administered With Tirzepatide in Adult Participants With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight: A Phase 3b, Randomized, Multicenter, Open-Label Study (TOGETHER-PsO)

Phase 3 · Completed · Eli Lilly and Company

Efficacy and Safety of Ixekizumab or Ixekizumab Concomitantly Administered With Tirzepatide in Adult Participants With Active Psoriatic Arthritis and Obesity or Overweight: A Phase 3b, Randomized, Multicenter, Open-Label Study (TOGETHER-PsA)

Phase 3 · Completed · Eli Lilly and Company

Evidence coverage

8 treatments

How much of this condition's readable clinical evidence the confidence engine has incorporated, across its most-studied treatments. This measures coverage of the evidence base — not whether any treatment works.

Partial evidence coverage
52% · 124/240 eligible items incorporated

Largest gap: off claim endpoint family (8, endpoint-family).

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20192025
Most influential

Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview.

Journal of diabetes research · 2019 · 222 cites
Recent publications

Preconception use of GLP-1 and GLP-1/GIP receptor agonists for obesity treatment.

Best practice & research. Clinical endocrinology & metabolism · 2025

Determinants of Maternal Insulin Resistance during Pregnancy: An Updated Overview.

Journal of diabetes research · 2019 · 222 cites
Major themes8
  • Anti-Obesity Agents1
  • Diet1
  • Glucagon-Like Peptide 11
  • Glucagon-Like Peptide-1 Receptor Agonists1
  • Insulin Resistance1
  • Obesity1
  • Preconception Care1
  • Pregnancy in Obesity1
Leading journals2
  • Best practice & research. Clinical endocrinology & metabolism1
  • Journal of diabetes research1
Leading researchers7
  • Fuglsang J1
  • Janež A1
  • Jensterle M1
  • Kampmann U1
  • Knorr S1
  • Koceva A1
  • Ovesen P1
Affiliations (unnormalised)4
  • Aarhus University Hospital1
  • Steno Diabetes Center Aarhus1
  • University Medical Center Ljubljana1
  • University Medical Center Maribor1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

BODY MASS INDEX in PREGNANT PEOPLE that is excessively above the recommended cut-off.

Identifiers
MeSHPregnancy in Obesity
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.