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Disease

Prehypertension

Late-stage therapeutic developmentEmerging research
MeSHPrehypertension
1
Publications
10
Clinical trials
2017
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones.
Major developments
Major clinical milestoneWorth watching
Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes
Primary completion2025-09-01
Clinical Milestones1View
Recently completed 1
Activity timeline1

Clinical trials

8 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
10
All trials
1
Active
5
Late-stage
6
Completed
Late-stage studies

Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes

Phase 4 · Recruiting · XueQing Yu

Effect of Dapagliflozin on Blood Pressure Variability in Patients With Prediabetes and Prehypertension Without Pharmacological Treatment

Phase 4 · Completed · University of Guadalajara

Nebivolol and Endothelial Regulation of Fibrinolysis

Phase 4 · Completed · University of Colorado, Boulder

A Randomized, Double-Blind, Placebo Control Trial Comparing Effects and Safety of TAURINE GRANULE and Placebo on Blood Pressure in Prehypertensive.

Phase 3 · Completed · Zhiming Zhu

Treatment of Uric Acid With the Xanthine Oxidase Inhibitor Febuxostat: Effects on Blood Pressure, Metabolic Markers, and Aortic Stiffness in Prehypertensive

Phase 4 · Completed · University of California, San Diego
Recently completed

Effect of Dapagliflozin on Blood Pressure Variability in Patients With Prediabetes and Prehypertension Without Pharmacological Treatment

Phase 4 · Completed · University of Guadalajara

Nebivolol and Endothelial Regulation of Fibrinolysis

Phase 4 · Completed · University of Colorado, Boulder

A Prospective, Vehicle Controlled, Double Blinded, Multicenter, Randomized, Phase II Study of B244 Delivered as a Topical Spray to Determine Safety and Efficacy in Subjects With Elevated Blood Pressure

Phase 2 · Completed · AOBiome LLC

A Randomized, Double-Blind, Placebo Control Trial Comparing Effects and Safety of TAURINE GRANULE and Placebo on Blood Pressure in Prehypertensive.

Phase 3 · Completed · Zhiming Zhu

Korean Life-Style Modification Effects on Blood Pressure

N/A · Completed · Yonsei University

Treatment of Uric Acid With the Xanthine Oxidase Inhibitor Febuxostat: Effects on Blood Pressure, Metabolic Markers, and Aortic Stiffness in Prehypertensive

Phase 4 · Completed · University of California, San Diego

Evidence coverage

8 treatments

How much of this condition's readable clinical evidence the confidence engine has incorporated, across its most-studied treatments. This measures coverage of the evidence base — not whether any treatment works.

Substantial evidence coverage
61% · 59/97 eligible items incorporated
lowers systolic blood pressure in hypertension51%
lowers diastolic blood pressure in hypertension42%

Largest gap: no meaningful change (9, trial-readability).

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Gut microbiota dysbiosis contributes to the development of hypertension.

Microbiome · 2017 · 1,229 cites
Recent publications

Gut microbiota dysbiosis contributes to the development of hypertension.

Microbiome · 2017 · 1,229 cites
Major themes1
  • Fecal Microbiota Transplantation1
Leading journals1
  • Microbiome1
Leading researchers8
  • Auguste K1
  • Cai J1
  • Chen J1
  • Chen L1
  • Cui Q1
  • Geng B1
  • Li J1
  • Liu W1
Affiliations (unnormalised)6
  • Baoding NO.1 Central Hospital1
  • Beijing ChaoYang Hospital1
  • Beijing Key Laboratory of Hypertension1
  • CAS Key Laboratory of Pathogenic Microbiology and Immunology1
  • Centre for Noncoding RNA Medicine1
  • Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.

Identifiers
MeSHPrehypertension
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.