Proteostasis Deficiencies
Recent clinical, regulatory, research and industry developments relating to this disease.
In vivo aspects of protein folding and quality control.
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes4
- Alzheimer Disease1
- Brain Ischemia1
- Protein Folding1
- Proteostasis Deficiencies1
Leading journals3
- Experimental & molecular medicine1
- International journal of molecular sciences1
- Science (New York, N.Y.)1
Leading researchers6
- Balchin D1
- Ciechanover A1
- Hartl FU1
- Hayer-Hartl M1
- Kwon YT1
- Pluta R1
Affiliations (unnormalised)4
- 1] Protein Metabolism Medical Research Center and Department of Biomedical Sciences1
- Max Planck Institute of Biochemistry1
- Medical University of Lublin1
- Protein Metabolism Medical Research Center and Department of Biomedical Sciences1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
Disorders caused by imbalances in the PROTEIN HOMEOSTASIS network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.