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Disease

Protozoan Infections

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHProtozoan Infections
3
Publications
5
Clinical trials
12
Associated genes
3
Related proteins
2023
Latest publication
Current focus
Protachykinin-1 biologyTherapeutic developmentInflammation & immunity
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones (1 completed or reporting results).
Clinical Milestones1View
Results posted 1
Activity timeline1

Clinical trials

4 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
5
All trials
1
Active
1
Late-stage
4
Completed
Recently completed

An Open Label Phase 1b Study to Characterise the Pharmacokinetic/Pharmacodynamic Relationship and Safety of MMV367 in Healthy Adult Participants Experimentally Infected With Blood Stage Plasmodium Falciparum

Phase 1 · Completed · Medicines for Malaria Venture

A Single Centre, Open Label, Pilot Phase Ib Study to Investigate Blood Stage Malaria Infection After Direct Venous Inoculation of Cryopreserved P. Falciparum (NF54 Strain) Sporozoites (PfSPZ-DVI) in Malaria naïve Healthy Adult Volunteers

Phase 1 · Completed · Medicines for Malaria Venture

Randomized, Double-blind, Placebo-controlled Sequential Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SCYX-7158 After Single Oral Ascending Doses in Healthy Male Volunteers

Phase 1 · Completed · Drugs for Neglected Diseases

A Double-Blind, Placebo-Controlled Trial of Albendazole in HIV-Positive Patients With Intestinal Microsporidiosis

Phase 3 · Completed · SmithKline Beecham

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20072023
Recent publications

Teleost innate immunity, an intricate game between immune cells and parasites of fish organs: who wins, who loses.

Frontiers in immunology · 2023 · 29 cites

IL-10: the master regulator of immunity to infection.

Journal of immunology (Baltimore, Md. : 1950) · 2008 · 1,647 cites

Waterborne transmission of protozoan parasites: a worldwide review of outbreaks and lessons learnt.

Journal of water and health · 2007 · 423 cites
Major themes4
  • Disease Outbreaks1
  • Global Health1
  • Parasites1
  • Protozoan Infections1
Leading journals3
  • Frontiers in immunology1
  • Journal of immunology (Baltimore, Md. : 1950)1
  • Journal of water and health1
Leading researchers8
  • Blount DG1
  • Bosi G1
  • Carosi A1
  • Couper KN1
  • Giari L1
  • Karanis P1
  • Kourenti C1
  • Lorenzoni M1
Affiliations (unnormalised)5
  • London School of Hygiene and Tropical Medicine1
  • National Research Center for Protozoan Diseases1
  • University of Ferrara1
  • University of Milan1
  • University of Perugia1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

PTPRD0.36EDN20.34MTCL10.34GATB0.33COL13A10.32NAA110.31GORAB0.31HERC60.31NOX40.31MDGA20.30LRRC70.29ARK2C0.29

Disease biology

3 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

NADPH oxidase 4via NOX40.31Protachykinin-1via TAC10.24Interleukin-11 receptor subunit alphavia IL11RA0.18

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Infections with unicellular organisms formerly members of the subkingdom Protozoa.

Identifiers
MeSHProtozoan Infections
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.