Psychotic Disorders

The supplied literature supports an association between psychosis and childhood adversity, including sexual abuse, physical abuse, emotional or psychological abuse, neglect, parental death, and bullying. It also supports psychosocial stressors as a risk factor for mental illness more broadly, with neuroinflammation proposed as a mediating pathway.

The grounding supports a model in which psychosocial stress may contribute to neuroinflammation, including elevated microglial activity, in the development of mental illness. It also describes psychosis-related mechanisms involving dysregulated thalamic activity, thalamocortical dysrhythmia, altered thalamic filtering of internal and external information, and downstream disruption of cortical network modulation.

Childhood adversity is supported as a risk factor, including abuse, neglect, parental death, and bullying. Psychosocial stressors are also described as a well-documented risk factor for mental illness and are relevant to psychosis in the supplied reviews.

The supplied grounding supports treatment at the level of drug therapy, therapy, and prevention and control, but it does not specify particular modalities or drug classes. It also notes that persons with schizophrenia are often excluded from psychedelic-assisted therapy because of concern about triggering or worsening psychosis, indicating that psychedelics are not standard treatment in this context.