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Disease

Puberty, Precocious

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHPuberty, Precocious
3
Publications
6
Clinical trials
2025
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones.
Major developments
Trial discontinuedWorth watching
Research of Integrated Traditional Chinese and Western Medicine on Precocious Puberty
Withdrawn2026-05-10
Clinical Milestones1View
Other updates 1
Activity timeline1

Clinical trials

4 sponsors · 1 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
6
All trials
0
Active
2
Late-stage
5
Completed
Recently completed

Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Precocious Puberty

N/A · Completed · Region Örebro County

A Phase 3, Randomized, Multi-Center, Open-Label Study to Evaluate the Efficacy and Safety of Leuprolide Acetate 11.25 and 30 mg Formulations in Children With Central Precocious Puberty

Phase 3 · Completed · Abbott

An Open-label, Non-Comparative Trial to Evaluate the Safety, Efficacy and Pharmacokinetics of Faslodex (Fulvestrant) in Girls With Progressive Precocious Puberty Associated With McCune-Albright Syndrome

Phase 2 · Completed · AstraZeneca

Study of Lupron Depot In The Treatment of Central Precocious Puberty

Phase 3 · Completed · Abbott

An Open-label, Non-comparative, Multi-centre Study to Assess the Efficacy and Safety of Bicalutamide When Used in Combination With Anastrozole for the Treatment of Gonadotropin-independent Precocious Puberty in Boys With Testotoxicosis

Phase 2 · Completed · AstraZeneca

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20032025
Major themes4
  • Puberty, Precocious2
  • Age Factors1
  • Luteinizing Hormone1
  • Mental Disorders1
Leading journals3
  • Endocrine reviews1
  • Frontiers in endocrinology1
  • JAMA network open1
Leading researchers8
  • Bai H1
  • Bourguignon JP1
  • Dinkelbach L1
  • Fang Y1
  • Grasemann C1
  • Hirtz R1
  • Juul A1
  • Kiewert C1
Affiliations (unnormalised)6
  • Center for Child and Adolescent Medicine1
  • Division of Rare Diseases and Center for Rare Diseases Ruhr1
  • Institute of Medical Informatics1
  • Institute of Sex- and Gender-Sensitive Medicine1
  • Postgraduate Training Base of Lianyungang First People's Hospital of Jinzhou Medical University1
  • The First People's Hospital of Lianyuangang1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.

Identifiers
MeSHPuberty, Precocious
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.