Back to discover
Disease

Pulmonary Aspergillosis

Late-stage therapeutic developmentEmerging research
MeSHPulmonary Aspergillosis
1
Publications
17
Clinical trials
2021
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones4View
Results posted 1
Results expected 2
Recently completed 1
Activity timeline4

Clinical trials

11 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
17
All trials
5
Active
6
Late-stage
6
Completed
Late-stage studies

Therapeutic Efficacy Comparison of a Six-month Treatment by Itraconazole and Nebulised Ambisome® Versus Treatment by Itraconazole Alone in Non- or Mildly- Immunocompromised Patients with Chronic Pulmonary Aspergillosis: a Prospective, Randomized, Single Blind Study, (single Aspergilloma Excluded)

Phase 3 · Recruiting · Poitiers University Hospital

A Randomized Controlled Trial to Compare Nebulized Amphotericin B and Nebulized Normal Saline as Maintenance in Increasing Time to Relapse in Patients With Chronic Pulmonary Aspergillosis Treated With 12 Months of Oral Itraconazole

Phase 3 · Recruiting · Post Graduate Institute of Medical Education and Research, Chandigarh

A Randomized Controlled Trial to Compare the Clinical Outcomes With Six Months of Therapy With Oral Itraconazole Versus Oral Voriconazole for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis

Phase 3 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh

A Randomized Controlled Trial to Compare the Clinical Outcomes of Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis

Phase 3 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh

A RANDOMIZED CONTROLLED STUDY OF ITRACONAZOLE IN CHRONIC CAVITARY PULMONARY ASPERGILLOSIS

Phase 4 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh

A Prospective, Randomized Trial Comparing The Safety, Tolerability, And Efficacy Of Voriconazole And Anidulafungin In Combination To That Of Voriconazole Alone When Used For Primary Therapy Of Invasive Aspergillosis in Pediatric Subjects Aged 2 to 17 Years

Phase 3 · Withdrawn · Pfizer
Recruiting

Therapeutic Efficacy Comparison of a Six-month Treatment by Itraconazole and Nebulised Ambisome® Versus Treatment by Itraconazole Alone in Non- or Mildly- Immunocompromised Patients with Chronic Pulmonary Aspergillosis: a Prospective, Randomized, Single Blind Study, (single Aspergilloma Excluded)

Phase 3 · Recruiting · Poitiers University Hospital

A Randomized Controlled Trial to Compare Nebulized Amphotericin B and Nebulized Normal Saline as Maintenance in Increasing Time to Relapse in Patients With Chronic Pulmonary Aspergillosis Treated With 12 Months of Oral Itraconazole

Phase 3 · Recruiting · Post Graduate Institute of Medical Education and Research, Chandigarh

Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study

Phase 2 · Recruiting · Manchester University NHS Foundation Trust

A Randomized Controlled Trial to Compare Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in Chronic Pulmonary and Allergic Bronchopulmonary Aspergillosis Overlap Syndrome

N/A · Recruiting · Post Graduate Institute of Medical Education and Research, Chandigarh
Recently completed

A Randomized Controlled Trial to Compare the Clinical Outcomes With Six Months of Therapy With Oral Itraconazole Versus Oral Voriconazole for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis

Phase 3 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh

A Randomized Controlled Open-label Study to Assess the Safety and Tolerability of Nebulized PC945 for Prophylaxis or Pre-emptive Therapy Against Pulmonary Aspergillosis in Lung Transplant Recipients (OPERA-S Study)

Phase 2 · Completed · Pulmocide Ltd

A Randomized Controlled Trial to Compare the Clinical Outcomes of Six Months Versus 12 Months of Oral Itraconazole Therapy for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis

Phase 3 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh

A Phase II Trial to Evaluate the Safety and Tolerability of Nebulised Amphotericin B Lipid Complex (ABELCET®) in the Prophylaxis of Invasive Pulmonary Aspergillosis During Prolonged Neutropenia in Paediatric Patients With Acute Leukaemia

Phase 2 · Completed · Fundació Sant Joan de Déu

A RANDOMIZED CONTROLLED STUDY OF ITRACONAZOLE IN CHRONIC CAVITARY PULMONARY ASPERGILLOSIS

Phase 4 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh

A Multicenter Phase II Study to Evaluate the Safety, Tolerability and Efficacy of Caspofungin as Prophylactic Treatment of Invasive Fungal Infections in Patients With Acute Leukemia Undergoing Induction Chemotherapy

Phase 2 · Completed · Northern Italy Leukemia Group

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Leading journals1
  • The Lancet. Infectious diseases1
Leading researchers8
  • Bassetti M1
  • Böll B1
  • Brüggemann R1
  • Chakrabarti A1
  • Chen SCA1
  • Colombo AL1
  • Cornely OA1
  • Gangneux JP1
Affiliations (unnormalised)6
  • Center of Expertise in Mycology Radboudumc/CWZ1
  • Centre for Infectious Diseases and Microbiology Laboratory Services1
  • Clinical and Translational Fungal-Working Group and Division of Infectious Diseases and Global Public Health1
  • College of Medicine1
  • Department of Clinical Mycology1
  • Duke University Medical Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Infections of the respiratory tract with fungi of the genus ASPERGILLUS.

Identifiers
MeSHPulmonary Aspergillosis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.