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Disease

Radiculopathy

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHRadiculopathy
3
Publications
20
Clinical trials
2025
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
Results expected Q4 20272026-04-13
Upcoming trial readoutImportant
Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery
Results expected Q1 20272026-02-17
Clinical Milestones4View
Results expected 4
Activity timeline4

Clinical trials

15 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
20
All trials
6
Active
14
Late-stage
6
Completed
Late-stage studies

Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

Phase 4 · Recruiting · Montefiore Medical Center

Prospective Controlled Crossover Study of the Role of Pentoxifylline in the Management of Lumbar Radiculopathy

Phase 4 · Active, not recruiting · St Joseph University, Beirut, Lebanon

Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery

Phase 4 · Recruiting · John O'Toole

The Effectiveness of Cervical Transforaminal Epidural Steroid Injection for the Treatment of Cervical Radicular Pain: A Prospective Cohort Study.

Phase 4 · Completed · University of Utah

Short-term Effectiveness of Gabapentin Versus Placebo in Acute Lumbosacral Radiculalgia by Herniation Disc: a Prospective, Multicentric, Randomized, Controlled, Double-blind Study

Phase 4 · Completed · Lille Catholic University

Open Randomised Comparative Study of the Efficacy and Safety of Neuromultivit (Solution for Injections, 2 ml) in Patients With Vertebrogenic Radiculopathy

Phase 3 · Completed · Bausch Health Americas, Inc.
Recruiting

Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.

Phase 4 · Recruiting · Montefiore Medical Center

A Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy

Phase 1 · Recruiting · Consano Bio

Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery

Phase 4 · Recruiting · John O'Toole

Exploring the Utility of [18F]3F4AP for Demyelination Imaging

Phase 1 · Recruiting · Yale University

Brain Mechanisms Supporting Cannabis-induced Pain Relief

Early Phase 1 · Recruiting · University of California, San Diego
Recently completed

Short-term Effectiveness of Gabapentin Versus Placebo in Acute Lumbosacral Radiculalgia by Herniation Disc: a Prospective, Multicentric, Randomized, Controlled, Double-blind Study

Phase 4 · Completed · Lille Catholic University

Efficacy of Intramuscular Glucocorticoid Injection in Patients With Lumbar Radicular Pain

Phase 4 · Completed · Cukurova University

The Effectiveness of Cervical Transforaminal Epidural Steroid Injection for the Treatment of Cervical Radicular Pain: A Prospective Cohort Study.

Phase 4 · Completed · University of Utah

A Prospective Randomized Comparative Trial of Targeted Injection Via a Transforaminal Approach With Dexamethasone Versus an Epidural Catheter Via an Interlaminar Approach With Particulate Steroid for the Treatment of Cervical Radicular Pain

Phase 4 · Completed · University of Utah

Open Randomised Comparative Study of the Efficacy and Safety of Neuromultivit (Solution for Injections, 2 ml) in Patients With Vertebrogenic Radiculopathy

Phase 3 · Completed · Bausch Health Americas, Inc.

Immediate Pain Relieving Effects of Sinbaro-3 Pharmaco-acupuncture in Low Back Pain Patients; A Randomized Controlled Trial

Phase 3 · Completed · Jaseng Hospital of Korean Medicine

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20162025
Major themes7
  • Electroacupuncture2
  • Radiculopathy2
  • Acupuncture Analgesia1
  • Neuronal Plasticity1
  • Receptors, AMPA1
  • Receptors, N-Methyl-D-Aspartate1
  • Spondylosis1
Leading journals3
  • Acupuncture in medicine : journal of the British Medical Acupuncture Society1
  • Brain and behavior1
  • Neurosurgery1
Leading researchers8
  • Yang P2
  • Zhang X2
  • Amirdelfan K1
  • Benyamin R1
  • Bundschu R1
  • Burgher AH1
  • Chen H1
  • Chen HY1
Affiliations (unnormalised)5
  • The First Affiliated Hospital of Guangxi University of Chinese Medicine2
  • *Center for Clinical Research and Carolina's Pain Institute1
  • Guangxi Key Laboratory of Molecular Biology of Preventive Medicine of Traditional Chinese Medicine1
  • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital1
  • The first school of clinical medicine1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.

Identifiers
MeSHRadiculopathy
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.