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Disease

Retinal Detachment

Late-stage therapeutic developmentEmerging research
MeSHRetinal Detachment
1
Publications
19
Clinical trials
10
Associated genes
1
Related proteins
2014
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2027.
  • 2 industry developments reported.
Upcoming Milestones
Major developments
Major clinical milestoneImportant
Dropless Pars Plana Vitrectomy Study
Primary completion2026-07-25
Upcoming trial readoutImportant
Retinal Displacement After Pars Plana Vitrectomy for Macula Involving Retinal Detachment: A Randomised Prospective Study Evaluating the Role of Intraoperative Perfluorocarbon Liquids
Results expected Q4 20272026-04-14
Clinical Milestones3View
Results expected 1
Recently completed 2
Industry & Market2View
Activity timeline5

Clinical trials

18 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
19
All trials
6
Active
11
Late-stage
6
Completed
Late-stage studies

Ursodeoxycholic Acid (UDCA) as a Neuroprotective Adjuvant Treatment to Rhegmatogenous Retinal Detachment Surgery

Phase 3 · Recruiting · Hopital Foch

Dropless Pars Plana Vitrectomy Study

Phase 4 · Recruiting · Massachusetts Eye and Ear Infirmary

A Multi-Center, Randomized, Double-Blind, Placebo Controlled, Study on the Use of Rho-Kinase Inhibitor to Reduce Ore Prevent Proliferative Vitreoretinopathy (PVR) in Eyes With Rhegmatogenous Retinal Detachment (RRD) at High Risk of PVR

Phase 2/3 · Active, not recruiting · Wills Eye

Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy: Results of the Pan-American Collaborative Retina Study (PACORES) Group

Phase 3 · Completed · J. Fernando Arevalo, MD FACS

Using Intraoperative Triamcinolone Acetonide Irrigation to Reduce Post-Operative Pain From Scleral Buckle Surgery

Phase 4 · Completed · Virginia Polytechnic Institute and State University

Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.

Phase 3 · Completed · Universitätsklinikum Köln
Recruiting

Ursodeoxycholic Acid (UDCA) as a Neuroprotective Adjuvant Treatment to Rhegmatogenous Retinal Detachment Surgery

Phase 3 · Recruiting · Hopital Foch

Dropless Pars Plana Vitrectomy Study

Phase 4 · Recruiting · Massachusetts Eye and Ear Infirmary

Prevention of ProliFerative Vitreoretinopathy with Intravitreal MethotreXate in Primary Retinal DEtachment Repair (FIXER) Trial

Phase 2 · Recruiting · Cincinnati Eye Institute, Southwest Ohio

A Prospective Matched Cohort Study of Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy

Phase 2 · Recruiting · Unity Health Toronto

Retinal Displacement After Pars Plana Vitrectomy for Macula Involving Retinal Detachment: A Randomised Prospective Study Evaluating the Role of Intraoperative Perfluorocarbon Liquids

N/A · Recruiting · Norfolk and Norwich University Hospitals NHS Foundation Trust
Recently completed

A Phase 2, Randomized, Sham-Controlled, Single-Masked, Dose-Ranging, Multi-Center Study to Assess the Safety and Efficacy of Intravitreal ONL1204 Ophthalmic Solution in Subjects With Macula-off Rhegmatogenous Retinal Detachment

Phase 2 · Completed · ONL Therapeutics

Using Intraoperative Triamcinolone Acetonide Irrigation to Reduce Post-Operative Pain From Scleral Buckle Surgery

Phase 4 · Completed · Virginia Polytechnic Institute and State University

Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.

Phase 3 · Completed · Universitätsklinikum Köln

Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy: Results of the Pan-American Collaborative Retina Study (PACORES) Group

Phase 3 · Completed · J. Fernando Arevalo, MD FACS

The Effects of Triamcinolone Acetonide With Retrobulbar Anesthesia on Postoperative Pain Control Following Vitreoretinal Surgery

Phase 4 · Completed · Emory University

The Effect of Intravitreous Ranibizumab on Intra-Operative Bleeding During Pars Plana Vitrectomy for Diabetic Traction Retinal Detachment

Phase 2 · Completed · University of Sao Paulo

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Leading journals1
  • Lancet (London, England)1
Leading researchers8
  • Barnard AR1
  • Black GC1
  • Clark KR1
  • Cottriall CL1
  • Cremers FP1
  • Downes SM1
  • During MJ1
  • Groppe M1
Affiliations (unnormalised)6
  • Clinical Neurosciences Group1
  • College of Medicine1
  • Department of Human Genetics and Nijmegen Center for Molecular Life Sciences1
  • Manchester Centre for Genomic Medicine1
  • Moorfields Eye Hospital NHS Foundation Trust and NIHR Ophthalmology Biomedical Research Centre1
  • National Heart and Lung Institute1

Associated genes

10 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

COL22A10.51FAT30.41BMP30.41GRM50.40CPAMD80.37VSX20.36SLC28A30.31CHD9NB0.14ARHGAP180.09DHRS90.09

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Metabotropic glutamate receptor 5via GRM50.40

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).

Identifiers
MeSHRetinal Detachment
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.