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Disease
Sciatica
Late-stage therapeutic developmentEmerging research
1
Publications
12
Clinical trials
2002
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Research2002-08-01The Journal of neuroscience : the official journal of the Society for Neuroscience
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
- Q4 2026A Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy
- Q4 2026Efficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and Sciatica
- Q1 2027Brain Mechanisms Supporting Cannabis-induced Pain Relief
Major developments
Upcoming trial readoutHigh impact
Results expected Q4 20262026-05-12
Upcoming trial readoutImportant
Results expected Q1 20272026-06-03
Clinical MilestonesViewHide
Results expected
- 2026-06-03Brain Mechanisms Supporting Cannabis-induced Pain ReliefResults expected Q1 2027
- 2026-05-12Efficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and SciaticaResults expected Q4 2026
- 2026-03-17A Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral RadiculopathyResults expected Q4 2026
Recently completed
- 2025-12-01Transforaminal Epidural Injection in Acute SciaticaPrimary completion
Activity timeline4
- 2026-06-03ClinicalBrain Mechanisms Supporting Cannabis-induced Pain ReliefResults expected Q1 2027
- 2026-05-12ClinicalEfficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and SciaticaResults expected Q4 2026
- 2026-03-17ClinicalA Phase 1, Randomized, Double-Blind, Single Dose Escalation Study to Assess the Safety and Tolerability of Transforaminal Epidural Administration of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral RadiculopathyResults expected Q4 2026
- 2025-12-01ClinicalTransforaminal Epidural Injection in Acute SciaticaPrimary completion
Clinical trials
The current development programme across all trial phases.
Clinical programme
12
4
6
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Most influential
Major themes1
- Neural Inhibition1
Leading journals1
- The Journal of neuroscience : the official journal of the Society for Neuroscience1
Leading researchers6
- Baba H1
- Karchewski LA1
- Kohno T1
- Moore KA1
- Scholz J1
- Woolf CJ1
Affiliations (unnormalised)1
- Massachusetts General Hospital and Harvard Medical School1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.