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Disease

Sciatica

Late-stage therapeutic developmentEmerging research
MeSHSciatica
1
Publications
12
Clinical trials
2002
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord.

Research2002-08-01The Journal of neuroscience : the official journal of the Society for Neuroscience

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2026.
  • 3 industry developments reported.
Upcoming Milestones
Clinical Milestones3View
Results expected 2
Recently completed 1
Industry & Market3View
Activity timeline6

Clinical trials

11 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
12
All trials
3
Active
6
Late-stage
6
Completed
Late-stage studies

Efficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and Sciatica

Phase 4 · Recruiting · Primus Pharmaceuticals

NSAIDs in Sciatica (NIS), an Investigator Initiated Randomised Placebo Controlled Trial of Naproxen

Phase 4 · Completed · Ostfold Hospital Trust

A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg

Phase 4 · Completed · Hadassah Medical Organization

Efficacy of TNF-alpha Inhibition in Sciatica With Post-operative Lumbar Spinal Fibrosis

Phase 3 · Completed · Assistance Publique - Hôpitaux de Paris

Efficacy of Soluble Dexamethasone by Echo-guided Infiltration Through the Sacrococcygeal Hiatus in Refractory Sciatica: a Prospective Randomised Double-blind Study Versus Placebo

Phase 3 · Completed · Nantes University Hospital

Open Randomized Study on the Efficacy of corticoïd Infiltration Versus Physiological Solution Infiltration Versus Feigning of Infiltration Via Sacro-coccygien Hiatus Versus Natural Evolution in Discal Sciatica

Phase 3 · Terminated · Nantes University Hospital
Recently completed

NSAIDs in Sciatica (NIS), an Investigator Initiated Randomised Placebo Controlled Trial of Naproxen

Phase 4 · Completed · Ostfold Hospital Trust

A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg

Phase 4 · Completed · Hadassah Medical Organization

Efficacy of Soluble Dexamethasone by Echo-guided Infiltration Through the Sacrococcygeal Hiatus in Refractory Sciatica: a Prospective Randomised Double-blind Study Versus Placebo

Phase 3 · Completed · Nantes University Hospital

A Prospective, Single-Center, Double-Blind, Placebo-Controlled Trial of BOL-DP-o-04 in Patients With Low Back Pain and Sciatica

Phase 1/2 · Completed · Breath of Life International Pharma Ltd

Efficacy of TNF-alpha Inhibition in Sciatica With Post-operative Lumbar Spinal Fibrosis

Phase 3 · Completed · Assistance Publique - Hôpitaux de Paris

Morphine, Nortriptyline and Their Combination in Sciatica Treatment

Phase 2 · Completed · National Institute of Dental and Craniofacial Research (NIDCR)

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002 · 592 cites
Recent publications

Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002 · 592 cites
Major themes1
  • Neural Inhibition1
Leading journals1
  • The Journal of neuroscience : the official journal of the Society for Neuroscience1
Leading researchers6
  • Baba H1
  • Karchewski LA1
  • Kohno T1
  • Moore KA1
  • Scholz J1
  • Woolf CJ1
Affiliations (unnormalised)1
  • Massachusetts General Hospital and Harvard Medical School1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.

Identifiers
MeSHSciatica
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.