Sexually Transmitted Diseases
Recent clinical, regulatory, research and industry developments relating to this disease.
Inflammatory mediators in bacterial vaginosis: The role of cytokines.
Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 3 clinical trials expected to report results, the earliest in Q3 2026.
- Q3 2026Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP
- Q4 2027Doxi-Rio: Pilot Implementation of Post-exposure Prophylaxis for Sexually Transmitted Infections With Doxycycline in Rio de Janeiro, Brazil
- Q4 2027Superiority of On-demand Pre-exposure Prophylaxis Versus Post-exposure Prophylaxis on Using Doxycycline for Preventing Sexually Transmitted Infections in Men Who Have Sex With Men
Clinical MilestonesViewHide
- 2026-06-16A Phase 1/2, Observer-blind, Randomized, Placebo-controlled Multi-country Study to Assess Safety and Efficacy of GSK Neisseria Gonorrhoeae GMMA (NgG) Investigational Vaccine When Administered to Healthy Adults 18 to 50 Years of AgeResults posted
- 2025-09-11Doxy-PEP: Dose-Ranging Study of Persons Receiving DoxycyclineResults posted
- 2026-06-05Superiority of On-demand Pre-exposure Prophylaxis Versus Post-exposure Prophylaxis on Using Doxycycline for Preventing Sexually Transmitted Infections in Men Who Have Sex With MenResults expected Q4 2027
- 2026-04-13Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEPResults expected Q3 2026
- 2026-03-30Doxi-Rio: Pilot Implementation of Post-exposure Prophylaxis for Sexually Transmitted Infections With Doxycycline in Rio de Janeiro, BrazilResults expected Q4 2027
- 2026-06-16ClinicalA Phase 1/2, Observer-blind, Randomized, Placebo-controlled Multi-country Study to Assess Safety and Efficacy of GSK Neisseria Gonorrhoeae GMMA (NgG) Investigational Vaccine When Administered to Healthy Adults 18 to 50 Years of AgeResults posted
- 2026-06-05ClinicalSuperiority of On-demand Pre-exposure Prophylaxis Versus Post-exposure Prophylaxis on Using Doxycycline for Preventing Sexually Transmitted Infections in Men Who Have Sex With MenResults expected Q4 2027
- 2026-04-13ClinicalRandomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEPResults expected Q3 2026
- 2026-03-30ClinicalDoxi-Rio: Pilot Implementation of Post-exposure Prophylaxis for Sexually Transmitted Infections With Doxycycline in Rio de Janeiro, BrazilResults expected Q4 2027
- 2025-09-11ClinicalDoxy-PEP: Dose-Ranging Study of Persons Receiving DoxycyclineResults posted
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Sexually Transmitted Diseases2
- Bacteria1
- Betacoronavirus1
- Bisexuality1
- HIV Infections1
- Homosexuality, Male1
- Mpox, Monkeypox1
- Proctitis1
Leading journals5
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica1
- JAMA network open1
- Journal of acquired immune deficiency syndromes (1999)1
- Lancet (London, England)1
- Science (New York, N.Y.)1
Leading researchers8
- Acosta-Velásquez KS1
- Agud-Dios M1
- Alemany A1
- Anglade V1
- Antón A1
- Arando M1
- Arroyo-Andrés J1
- Baggaley RC1
Affiliations (unnormalised)6
- Australian Research Centre in Sex1
- Bio21 Molecular Science and Biotechnology Institute1
- Center of Clinical Laboratory Medicine1
- Central Clinical School1
- Centre for Social Research in Health1
- Centre for Tropical Medicine and Global Health1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Sexually transmitted diseases are diseases that are caused by, or spread through, sexual contact. The term covers infections and related conditions transmitted during sexual behavior.
The grounding supports sexual contact as the route by which these diseases are propagated. It also links the topic to sexual behavior, including male homosexuality, as a co-studied mechanism, but does not support a more specific aetiology for the category as a whole.
The supplied material does not define a single biological mechanism for sexually transmitted diseases as a group. It does indicate that some sexually transmitted infections involve bacterial pathogens with antimicrobial resistance, and that bacterial vaginosis may alter cytokine levels and immune responses in the female reproductive tract.
Sexual behavior is the main supported risk factor in the grounding, because these diseases are propagated by sexual contact. The literature also highlights elevated STI risk in people using HIV preexposure prophylaxis and links bacterial vaginosis with acquisition of other STIs, but it does not support broader risk-factor statements for the category as a whole.
The grounding supports diagnosis as a covered aspect, but it does not provide a general treatment standard for sexually transmitted diseases as a category. It does indicate that antimicrobial-resistant bacterial pathogens are managed with antimicrobial treatment informed by surveillance and whole-genome sequencing, and that some STI-related contexts involve HIV preexposure prophylaxis programs, but not a unified standard-of-care modality for all sexually transmitted diseases.
AI-generated summary grounded in MeSH and 3 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Diseases due to or propagated by sexual contact.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.