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Disease

Shock, Cardiogenic

Late-stage therapeutic developmentEmerging researchRising momentum
10
Publications
8
Clinical trials
3
Related conditions
2024
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

Myocardial localization of coronavirus in COVID-19 cardiogenic shock.

Research2020-04-11European journal of heart failure

Intraaortic balloon support for myocardial infarction with cardiogenic shock.

Research2012-08-26The New England journal of medicine

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Clinical trials

7 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
8
All trials
3
Active
4
Late-stage
3
Completed
Late-stage studies

Research activity

10 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
19992024
Most influential
Recent publications
Major themes8
  • Shock, Cardiogenic3
  • Hospital Mortality2
  • American Heart Association1
  • Cardiology1
  • Heart Failure1
  • Hemodynamics1
  • Internationality1
  • Intra-Aortic Balloon Pumping1
Leading journals6
  • Circulation3
  • European journal of heart failure2
  • The New England journal of medicine2
  • Circulation. Heart failure1
  • JAMA1
  • Journal of cardiac failure1
Leading researchers8
  • Thiele H4
  • Katz JN3
  • Morrow DA3
  • Baird-Zars VM2
  • Berg DD2
  • Bohula EA2
  • Chaudhry SP2
  • Desch S2
Affiliations (unnormalised)6
  • Brigham and Women's Hospital3
  • Mayo Clinic2
  • St Vincent Heart Center2
  • University of Alberta2
  • University of California2
  • University of Utah2

Related conditions

3 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Disease profile

A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.

Overview

Cardiogenic shock is a high-acuity state of end-organ hypoperfusion caused by a marked reduction in cardiac output in the setting of heart disease. It is a complex and hemodynamically diverse syndrome that can progress to multisystem organ failure and death.

Causes

It develops after an acute cardiac insult or underlying heart disease that diminishes cardiac output. The supplied grounding does not specify particular etiologies beyond this general cardiac origin.

Pathophysiology

The core mechanism is inadequate cardiac pumping leading to reduced systemic perfusion and end-organ hypoperfusion. The syndrome is described as multifactorial and progressive, with an initial cardiac insult followed by organ failure and, in severe cases, death.

Risk factors

Underlying heart disease and an acute cardiac insult increase risk. The literature also indicates that a patient's broader cardiac condition and overall medical condition influence whether cardiogenic shock develops and how severe it becomes.

Current standard of care

Management includes best medical therapy, surgical approaches, mechanical circulatory support, and palliative care. Contemporary guidance also emphasizes timely, appropriately selected therapy, phenotyping of patients, and organized regional systems of care, but the supplied grounding does not support a more specific treatment hierarchy.

AI-generated summary grounded in MeSH and 2 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Shock resulting from diminution of cardiac output in heart disease.

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.