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Disease

Sinoatrial node dysfunction and deafness

Late-stage therapeutic development

Also known as SANDD.

20
Clinical trials
8
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones5View
Results expected 3
Recently completed 2
Activity timeline5

Clinical trials

17 sponsors · 2 new · 2 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
20
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator

Phase 4 · Recruiting · University of Rochester

Comparison of the Effectiveness of Oral and Intratympanic Corticosteroid Treatments in Patients Diagnosed With Sudden Sensorineural Hearing Loss

Phase 4 · Recruiting · Dr. Lutfi Kirdar Kartal Training and Research Hospital

A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group, Pivotal Trial to Assess the Efficacy and Safety of Sonlicromanol in Adult Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Variant

Phase 3 · Recruiting · Khondrion BV

Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm

Phase 3 · Recruiting · Ottawa Heart Institute Research Corporation

Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions

Phase 4 · Recruiting · Wroclaw Medical University

Colchicine After Electrocardioversion for Atrial Fibrillation - The COLECTRO-AF Trial

Phase 3 · Recruiting · University Hospital, Basel, Switzerland
Recruiting

Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator

Phase 4 · Recruiting · University of Rochester

Comparison of the Effectiveness of Oral and Intratympanic Corticosteroid Treatments in Patients Diagnosed With Sudden Sensorineural Hearing Loss

Phase 4 · Recruiting · Dr. Lutfi Kirdar Kartal Training and Research Hospital

A Phase III, Randomised, Double-blind, Placebo-controlled, Parallel-group, Pivotal Trial to Assess the Efficacy and Safety of Sonlicromanol in Adult Subjects With a Genetically Confirmed Mitochondrial DNA tRNALeu(UUR) m.3243A>G Variant

Phase 3 · Recruiting · Khondrion BV

Study Evaluating Dexmedetomidine in the Acute Treatment of Electrical Storm

Phase 3 · Recruiting · Ottawa Heart Institute Research Corporation

Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions

Phase 4 · Recruiting · Wroclaw Medical University

Colchicine After Electrocardioversion for Atrial Fibrillation - The COLECTRO-AF Trial

Phase 3 · Recruiting · University Hospital, Basel, Switzerland
Recently completed

Comparison of Single-syringe vs. Double-syringe Techniques for Adenosine Administration in Supraventricular Tachycardia: A Randomized Clinical Trial

Phase 4 · Completed · Hormozgan University of Medical Sciences

Comparison Of Post Operative Analgesic Effectiveness Of Ropivacane Plus Dexamethasone And Ropivacane Plus Dexmedetomidine In Trans Abdominal Plane Block In Stoma Reversal Under General Anesthesia

Phase 2/3 · Completed · Sahiwal medical college sahiwal

Determination of the 90% Effective Dose of the Initial Bolus of Norepinephrine in Elective Cesarean Section: An Up-Down Study

Phase 4 · Completed · Pontificia Universidad Catolica de Chile

Effect of Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, on Ventricular Repolarization Electrocardiographic Parameters in Type 2 Diabetes Patients: DAPA - ECG Study

Phase 4 · Completed · Beneficência Portuguesa de São Paulo

Evaluation of Ultrasound Guided Modified Pectoral Nerves Blocks in Transvenous Subpectoral Pacemaker Insertion in Children: Randomized Controlled Trial

Phase 4 · Completed · Kasr El Aini Hospital

A Two-part, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy and Safety Study of SENS-401 in Subjects With Severe or Profound Sudden Sensorineural Hearing Loss

Phase 2/3 · Completed · Sensorion

Associated genes

8 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

CACNA1D0.69PRR130.12CALHM60.05PIGO0.05AVPI10.05FASTKD50.04DECR20.03ATP6V1D0.03

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Voltage-dependent L-type calcium channel subunit alpha-1Dvia CACNA1D0.69

Reference

Authoritative identity, definition & identifiers.

Synonyms

SANDD

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.