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Disease

Sinusitis

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHSinusitis
3
Publications
20
Clinical trials
3
Related conditions
2021
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

Approval: Tezspire (EMA)

Regulatory2022-09-19EMA

International consensus statement on allergy and rhinology: rhinosinusitis 2021.

Research2021-03-01International forum of allergy & rhinology

Executive summary of EPOS 2020 including integrated care pathways.

Research2020-04-01Rhinology

EUFOREA consensus on biologics for CRSwNP with or without asthma.

Research2019-07-15Allergy

Approval: Dupixent (EMA)

Regulatory2017-09-26EMA

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2027.
  • 1 industry development reported.
Upcoming Milestones
Clinical Milestones6View
Results posted 1
Results expected 3
Recently completed 2
Industry & Market1View
Activity timeline7

Clinical trials

17 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
20
All trials
6
Active
17
Late-stage
6
Completed
Late-stage studies

SMART Use of Biologics in Chronic Rhinosinusitis With Nasal Polyposis

Phase 4 · Recruiting · Medical University of South Carolina

Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis

Phase 4 · Recruiting · Daniel Merenstein

Evaluation of the Efficacy of 3-month Continuous Extended Treatment With Azithromycin in Idiopathic Purulent Oedematous Sinusitis in Adults: a Multicentre Randomised Controlled Trial

Phase 3 · Recruiting · Centre Hospitalier Intercommunal Creteil

Efficacy of Alternate Dupilumab Schedule in Recurrent Chronic Rhinosinusitis With Nasal Polyposis Patients

Phase 4 · Active, not recruiting · Madigan Army Medical Center

A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of 611 in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Phase 3 · Active, not recruiting · Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.

A Randomized, Double-Blinded, Single Site Study to Evaluate the Efficacy of Erenumab for Treatment of Idiosyncratic Facial Pain Mimicking Rhinosinusitis

Phase 4 · Completed · David Jang, M.D.
Recently completed

ENLIGHTEN 2: A Phase III, Randomized, Blinded, Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults

Phase 3 · Completed · Lyra Therapeutics

Mechanisms of Smell Improvement With Dupilumab

Phase 4 · Completed · Medical University of South Carolina

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Dupilumab in Patients With Uncontrolled, Chronic Rhinosinusitis Without Nasal Polyposis (CRSsNP)

Phase 3 · Completed · Sanofi

A Randomized, Double-Blinded, Single Site Study to Evaluate the Efficacy of Erenumab for Treatment of Idiosyncratic Facial Pain Mimicking Rhinosinusitis

Phase 4 · Completed · David Jang, M.D.

Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit?

Phase 3 · Completed · Nader Shaikh

Prospective Randomized, Placebo-controlled Clinical Study to Study the Effect of Postoperative Additive Systemic Steroids in Chronic Rhinosinusitis With Nasal Polyps

Phase 4 · Completed · Friedrich-Alexander-Universität Erlangen-Nürnberg

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20192021
Major themes4
  • Delivery of Health Care, Integrated1
  • Rhinitis1
  • Rhinitis, Allergic1
  • Sinusitis1
Leading journals3
  • Allergy1
  • International forum of allergy & rhinology1
  • Rhinology1
Leading researchers8
  • Fokkens WJ3
  • Hopkins C3
  • Mullol J3
  • Bachert C2
  • Bernal-Sprekelsen M2
  • Desrosiers M2
  • Hellings PW2
  • Kern R2
Affiliations (unnormalised)6
  • University Hospitals Leuven3
  • Amsterdam University Medical Centres2
  • Eastern Virginia Medical School2
  • Karolinska Institute2
  • Northwestern University2
  • Nose and Ear Hospital2

Related conditions

3 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Rhinitis3Chronic Disease2Nasal Polyps2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.

Identifiers
MeSHSinusitis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.