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Disease

Sleep Disorders, Circadian Rhythm

Late-stage therapeutic developmentEmerging research
MeSHSleep Disorders, Circadian Rhythm
1
Publications
9
Clinical trials
2019
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials with recent milestones (1 completed or reporting results).
Clinical Milestones3View
Results posted 1
Recently completed 2
Activity timeline3

Clinical trials

8 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
9
All trials
3
Active
5
Late-stage
6
Completed
Late-stage studies

The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional)

Phase 4 · Recruiting · Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health

A Multicenter, Double-blind, Randomized Study to Evaluate the Effects of Tasimelteon vs. Placebo in Participants With Delayed Sleep-Wake Phase Disorder (DSWPD)

Phase 3 · Recruiting · Vanda Pharmaceuticals

A Double-Blind, Randomized, Two-Period Crossover Study to Evaluate the Effects of Tasimelteon Vs. Placebo in Subjects with Delayed Sleep-Wake Phase Disorder (DSWPD) and the CRY1Δ11 Variant

Phase 3 · Recruiting · Vanda Pharmaceuticals

Feasibility Study on the Use of Redormin® 500 (Ze 91019) on Day-time Cognition and Quality of Life in People With Occasional Sleep Problems

Phase 4 · Completed · Max Zeller Soehne AG

Multicenter, Randomized, Double-blind, Placebo Controlled Trial of 2 mg Melatonin for Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers

Phase 3 · Completed · Universitätsklinikum Hamburg-Eppendorf
Recently completed

High-frequency Transcranial Random Noise Stimulation (Hf-tRNS) for Sleep Disturbances in Neurocognitive Disorders Due to Vascular Disease

N/A · Completed · Chinese University of Hong Kong

Feasibility Study on the Use of Redormin® 500 (Ze 91019) on Day-time Cognition and Quality of Life in People With Occasional Sleep Problems

Phase 4 · Completed · Max Zeller Soehne AG

Multicenter, Randomized, Double-blind, Placebo Controlled Trial of 2 mg Melatonin for Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers

Phase 3 · Completed · Universitätsklinikum Hamburg-Eppendorf

Melatonin as a Circadian Clock Regulator, Neuromodulator and Myelo-protector in Adjuvant Breast Cancer Chemotherapy: a Randomized, Double-blind, Placebo-controlled Trial.

Phase 2 · Completed · Hospital de Clinicas de Porto Alegre

A Randomized, Double-Blind, Placebo-Controlled, Parallel, Proof of Concept Study to Evaluate the Effectiveness of Ramelteon to Advance the Timing of Sleep in Individuals With Delayed Sleep Phase Syndrome (DSPS)

Phase 2 · Completed · Takeda

An Evaluation of the Effects of Pharmaton® Caplets Film-coated Tablets on Mental Performance and Physical Fatigue in Nurses Working Night Shifts: a Double-blind, Placebo Controlled Pilot Trial

Phase 2 · Completed · Boehringer Ingelheim

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Genomics of circadian rhythms in health and disease.

Genome medicine · 2019 · 370 cites
Recent publications

Genomics of circadian rhythms in health and disease.

Genome medicine · 2019 · 370 cites
Major themes1
  • Genomics1
Leading journals1
  • Genome medicine1
Leading researchers2
  • Rijo-Ferreira F1
  • Takahashi JS1
Affiliations (unnormalised)2
  • Howard Hughes Medical Institute1
  • University of Texas Southwestern Medical Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Dyssomnias associated with disruption of the normal 24 hour sleep wake cycle secondary to travel (e.g., JET LAG SYNDROME), shift work, or other causes.

Identifiers
MeSHSleep Disorders, Circadian Rhythm
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.