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Disease

Spasm

Late-stage therapeutic developmentEmerging research
MeSHSpasm
1
Publications
19
Clinical trials
2020
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma.

Research2020-07-24Journal of clinical oncology : official journal of the American Society of Clinical Oncology

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones8View
Results posted 1
Results expected 3
Recently completed 3
Other updates 1
Activity timeline8

Clinical trials

17 sponsors · 1 new · 2 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
19
All trials
6
Active
13
Late-stage
6
Completed
Late-stage studies

Multicentre, Randomized, Controlled Clinical Trial on 7-day Followed by Maintenance Therapy for 10 Weeks vs. 14-day and no Maintenance Course of Prednisolone for the Treatment of Infantile Epileptic Spasms Syndrome (IESS)

Phase 4 · Active, not recruiting · University of Colombo

The Safety and Efficacy of DaxibotulinumtoxinA-Lanm for Benign Essential Blepharospasm and Hemifacial Spasm

Phase 4 · Recruiting · Montefiore Medical Center

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Multicenter Study To Examine The Efficacy And Safety Of ZX008 In Subjects With CDKL5 Deficiency Disorder Followed By An Open-Label Extension

Phase 3 · Active, not recruiting · Zogenix, Inc.

Effect of Intravenous Lidocaine Infusion on Duodenal Peristalsis, Sedation Quality and Rescue Spasmolytic Requirement in ERCP Procedures: A Randomized, Double-Blind, Placebo-Controlled Study

Phase 4 · Completed · Ankara City Hospital Bilkent

Efficacy and Safety of the Fixed-Dose Combination of Etoricoxib / Tizanidine Versus Etoricoxib in the Treatment of Patients With Acute Low Back Pain Associated to Muscle Spasm

Phase 3 · Completed · Laboratorios Silanes S.A. de C.V.

The Role of Oral Verapamil in Preventing Radial Spasm During Transradial Angiography

Phase 4 · Completed · Mersin Medicalpark Hastanesi
Recently completed

Effect of Intravenous Lidocaine Infusion on Duodenal Peristalsis, Sedation Quality and Rescue Spasmolytic Requirement in ERCP Procedures: A Randomized, Double-Blind, Placebo-Controlled Study

Phase 4 · Completed · Ankara City Hospital Bilkent

Efficacy and Safety of the Fixed-Dose Combination of Etoricoxib / Tizanidine Versus Etoricoxib in the Treatment of Patients With Acute Low Back Pain Associated to Muscle Spasm

Phase 3 · Completed · Laboratorios Silanes S.A. de C.V.

The Role of Oral Verapamil in Preventing Radial Spasm During Transradial Angiography

Phase 4 · Completed · Mersin Medicalpark Hastanesi

Topical Nitroglycerin Pretreatment for the Prevention of Radial Arterial Spasm

Phase 3 · Completed · University of Medicine and Pharmacy "Victor Babes" Timisoara

Nicardipine to Avoid Spasm in Trans Radial Percutaneous Coronary Intervention

Phase 3 · Completed · Pr. Semir Nouira

A Phase 3, 14-Day, Double-blind, Randomized, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Tolperisone in Subjects With Pain Due to Acute Back Muscle Spasm

Phase 3 · Completed · Neurana Pharmaceuticals, Inc.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020 · 373 cites
Recent publications

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020 · 373 cites
Leading journals1
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology1
Leading researchers8
  • Bahary N1
  • Bates SE1
  • Bullock AJ1
  • Chondros D1
  • de la Fouchardiere C1
  • Fazio N1
  • Hammel P1
  • Heinemann V1
Affiliations (unnormalised)6
  • and Université de Paris1
  • Beth Israel Deaconess Medical Center1
  • Catalan Institute of Oncology (ICO)1
  • Centre Léon Bérard1
  • Columbia University Irving Medical Center1
  • Department of Internal Medicine III and Comprehensive Cancer Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

An involuntary contraction of a muscle or group of muscles. Spasms may involve SKELETAL MUSCLE or SMOOTH MUSCLE.

Identifiers
MeSHSpasm
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.