Stiff-Person Syndrome
Recent clinical, regulatory, research and industry developments relating to this disease.
Successful use of anti-CD19 CAR T cells in severe treatment-refractory stiff-person syndrome.
Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial with recent milestones.
Clinical MilestonesViewHide
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes5
- Stiff-Person Syndrome2
- Antigens, CD191
- Cerebellar Ataxia1
- Immunotherapy, Adoptive1
- Nervous System Diseases1
Leading journals2
- Neurology(R) neuroimmunology & neuroinflammation1
- Proceedings of the National Academy of Sciences of the United States of America1
Leading researchers8
- Geis C2
- Bittner S1
- Borie D1
- Doppler K1
- Eisenhut K1
- Engels D1
- Faber J1
- Faissner S1
Affiliations (unnormalised)4
- From the Institute of Clinical Neuroimmunology (K.E.)1
- Jena University Hospital1
- Otto-von-Guericke University1
- Ruhr-University Bochum1
Reference
Authoritative identity, definition & identifiers.
A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.