Back to discover
Disease

Tinnitus

Late-stage therapeutic developmentEmerging research
MeSHTinnitus
3
Publications
19
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Major developments
Major trial resultsHigh impact
Treatment of Tinnitus With Migraine Medications: A Randomized Clinical Trial
Results posted2026-04-16
Upcoming trial readoutImportant
Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus
Results expected Q3 20262026-02-23
Clinical Milestones5View
Results posted 1
Results expected 3
Recently completed 1
Activity timeline5

Clinical trials

15 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
19
All trials
6
Active
9
Late-stage
6
Completed
Late-stage studies

Management of Acute Tinnitus With Migraine Medications: A Randomized Clinical Trial

Phase 4 · Active, not recruiting · University of California, Irvine

Efficacy of Donepezil in Patients With Chronic Tinnitus

Phase 4 · Active, not recruiting · University of Sao Paulo

A Randomized, Double-Blind, Placebo-Controlled, Clinical Evaluation of the Efficacy, Safety and Tolerability of Neramexane in Patients With Subjective Tinnitus

Phase 3 · Completed · Merz Pharmaceuticals GmbH

Treatment of Tinnitus With Migraine Medications: A Randomized Clinical Trial

Phase 4 · Completed · University of California, Irvine

Efficacy and Safety of AM-101 in the Treatment of Acute Peripheral Tinnitus 3

Phase 3 · Completed · Auris Medical AG

Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial

Phase 4 · Completed · Washington University School of Medicine
Recruiting

Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus

Phase 2 · Recruiting · Wayne State University

An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus

Early Phase 1 · Recruiting · D. Bradley Welling, MD, PhD

Implantation of an Auditory Brainstem Implant for the Treatment of Incapacitating Unilateral Tinnitus

N/A · Recruiting · University Medical Center Groningen

Effects of Cochlear Implantation on Tinnitus and Its Symptoms

N/A · Recruiting · Chinese PLA General Hospital
Recently completed

Treatment of Tinnitus With Migraine Medications: A Randomized Clinical Trial

Phase 4 · Completed · University of California, Irvine

A Randomized, Double-blind, Placebo-controlled Phase 2 Study of OTO-313 Given as a Single Intratympanic Injection in Subjects With Unilateral Subjective Tinnitus

Phase 2 · Completed · Otonomy, Inc.

Efficacy and Safety of AM-101 in the Treatment of Acute Peripheral Tinnitus 3

Phase 3 · Completed · Auris Medical AG

Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial

Phase 4 · Completed · Washington University School of Medicine

A Multicenter, Randomized, Double-blind, Placebo- Controlled, Cross-over, Proof of Concept Study Comparing the Effects of Both Single Dose and Repeated Dosing Treatment for 2 Weeks of BGG492 in Patients With Chronic Subjective Tinnitus

Phase 2 · Completed · Novartis Pharmaceuticals

A Randomized, Double-Blind, Placebo-Controlled, Clinical Evaluation of the Efficacy, Safety and Tolerability of Neramexane in Patients With Subjective Tinnitus

Phase 3 · Completed · Merz Pharmaceuticals GmbH

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20112023
Most influential

Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011 · 706 cites

Cortical surface plasticity promotes map remodeling and alleviates tinnitus in adult mice.

Progress in neurobiology · 2023 · 7 cites

Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons.

Cellular and molecular neurobiology · 2023 · 5 cites
Recent publications

Cortical surface plasticity promotes map remodeling and alleviates tinnitus in adult mice.

Progress in neurobiology · 2023 · 7 cites

Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons.

Cellular and molecular neurobiology · 2023 · 5 cites

Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model.

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011 · 706 cites
Major themes5
  • Tinnitus2
  • Auditory Cortex1
  • Computer Simulation1
  • Hearing Loss1
  • Models, Biological1
Leading journals3
  • Cellular and molecular neurobiology1
  • Progress in neurobiology1
  • The Journal of neuroscience : the official journal of the Society for Neuroscience1
Leading researchers8
  • Baeg E1
  • Gross J1
  • Knipper M1
  • Lee M1
  • Lee S1
  • Mazurek B1
  • McAlpine D1
  • Pak S1
Affiliations (unnormalised)5
  • City University of Hong Kong1
  • Incheon National University1
  • Tinnitus Center1
  • Tübingen Hearing Research Center (THRC)1
  • University College London Ear Institute1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.

Identifiers
MeSHTinnitus
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.