Tinnitus
Recent clinical, regulatory, research and industry developments relating to this disease.
Cortical surface plasticity promotes map remodeling and alleviates tinnitus in adult mice.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q3 2027.
- Q3 2027A Prospective, Multicentric, Feasibility Investigation to Assess the Effect of the Tinnitus Implant on Tinnitus Loudness in Adults With Moderate to Severe Chronic Tinnitus Accompanied by Normal Hearing to Moderately Severe Hearing Loss.
- Q4 2027An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus
Clinical MilestonesViewHide
- 2026-04-16Treatment of Tinnitus With Migraine Medications: A Randomized Clinical TrialResults posted
- 2026-06-02A Prospective, Multicentric, Feasibility Investigation to Assess the Effect of the Tinnitus Implant on Tinnitus Loudness in Adults With Moderate to Severe Chronic Tinnitus Accompanied by Normal Hearing to Moderately Severe Hearing Loss.Results expected Q3 2027
- 2025-12-02An fMRI Investigation of the Effects of IV Lidocaine on TinnitusResults expected Q4 2027
- 2026-10-01Evaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS)Primary completion
- 2026-09-30Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced TinnitusPrimary completion
- 2025-12-09Efficacy of Donepezil in Patients With Chronic TinnitusPrimary completion
- 2026-10-01ClinicalEvaluation of Deep Brain Stimulation (DBS) of the Right Operculum 3 (OP3) in Permanent Non-pulsatile Disabling Tinnitus (TINNOP3-DBS)Primary completion
- 2026-09-30ClinicalClinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced TinnitusPrimary completion
- 2026-06-02ClinicalA Prospective, Multicentric, Feasibility Investigation to Assess the Effect of the Tinnitus Implant on Tinnitus Loudness in Adults With Moderate to Severe Chronic Tinnitus Accompanied by Normal Hearing to Moderately Severe Hearing Loss.Results expected Q3 2027
- 2026-04-16ClinicalTreatment of Tinnitus With Migraine Medications: A Randomized Clinical TrialResults posted
- 2025-12-09ClinicalEfficacy of Donepezil in Patients With Chronic TinnitusPrimary completion
- 2025-12-02ClinicalAn fMRI Investigation of the Effects of IV Lidocaine on TinnitusResults expected Q4 2027
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes5
- Tinnitus2
- Auditory Cortex1
- Computer Simulation1
- Hearing Loss1
- Models, Biological1
Leading journals3
- Cellular and molecular neurobiology1
- Progress in neurobiology1
- The Journal of neuroscience : the official journal of the Society for Neuroscience1
Leading researchers8
- Baeg E1
- Gross J1
- Knipper M1
- Lee M1
- Lee S1
- Mazurek B1
- McAlpine D1
- Pak S1
Affiliations (unnormalised)5
- City University of Hong Kong1
- Incheon National University1
- Tinnitus Center1
- Tübingen Hearing Research Center (THRC)1
- University College London Ear Institute1
Reference
Authoritative identity, definition & identifiers.
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.