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Disease

Urinary Incontinence

Late-stage therapeutic developmentEmerging research
MeSHUrinary Incontinence
1
Publications
18
Clinical trials
2026
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 6 clinical trials expected to report results, the earliest in Q3 2026.
  • Active recent publication activity, including 1 notable finding.
Upcoming Milestones
Research Highlights1View
Clinical Milestones11View all 11
Results posted 2
Results expected 5
Recently completed 1
Other updates 2
+3 more in the activity timeline below
Activity timeline12

Therapeutic landscape

Therapies with a regulatory footing for this condition, alongside the wider set of agents co-studied with it in the literature.

Approved & established therapies
Fesoterodine fumarateapproved

Approval — Treatment of the symptoms (increased urinary frequency and / or urgency and / or urgency… (2007)

Darifenacin hydrobromideapproved

Approval — Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency… (2004)

Duloxetine Hydrochlorideapproved

Approval — Yentreve is indicated for women for the treatment of moderate to severe stress urinary in… (2004)

Oxybutyninapproved

Approval — Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency… (2004)

Clinical trials

17 sponsors · 2 new · 2 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
17
Late-stage
6
Completed
Late-stage studies

Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence

Phase 4 · Active, not recruiting · Women and Infants Hospital of Rhode Island

A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight

Phase 3 · Recruiting · Eli Lilly and Company

Assessing the Utility of Prophylactic Antibiotics at Time of Urethral Bulking Using Bulkamid

Phase 4 · Recruiting · Ohio State University

Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)

Phase 4 · Active, not recruiting · University of Aarhus

CELLEBRATE: A Double-Blind, Randomized, Controlled Trial Comparing the Safety and Efficacy of AMDC-USR With Placebo in Female Subjects With Persistent or Recurrent Stress Urinary Incontinence Following Surgical Treatment

Phase 3 · Active, not recruiting · Cook MyoSite

Comparison Between the Effect of Periurethral Injection of Platelet-rich Plasma VS Platelet Rich Fibrin in Treatment of Female Stress Urinary Incontinence

Phase 3 · Completed · Kafrelsheikh University
Recently completed

Comparison Between the Effect of Periurethral Injection of Platelet-rich Plasma VS Platelet Rich Fibrin in Treatment of Female Stress Urinary Incontinence

Phase 3 · Completed · Kafrelsheikh University

Investigation of Brain Mechanisms Involved in Urgency Urinary Incontinence

Phase 4 · Completed · Becky Clarkson

The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling: A Randomized Placebo Controlled Trial

Phase 4 · Completed · West Penn Allegheny Health System

Use of a Dual-agent Local Analgesic (Bupivacaine-meloxicam) for Abdominal Incisions in Patients Undergoing Retropubic Mid-urethral Sling Surgery

Phase 3 · Completed · TriHealth Inc.

Treatment for Mixed Urinary Incontinence: Mid-urethral Sling vs. Botox A

Phase 3 · Completed · NICHD Pelvic Floor Disorders Network

The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence

Phase 4 · Completed · Northwestern University

Regulatory timeline

Drug regulatory events matched to this condition by indication — EMA.

First approvals
2007emaApproval — Fesoterodine fumarate· Treatment of the symptoms (increased urinary frequency and / or urgency and / or urgency incontinence) that may occur in patients with overactive-bladder syndrome. source ↗
2004emaApproval — Darifenacin hydrobromide· Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in adult patients with overactive bladder syndrome. source ↗
2004emaApproval — Duloxetine Hydrochloride· Yentreve is indicated for women for the treatment of moderate to severe stress urinary incontinence (SUI). source ↗
2004emaApproval — Oxybutynin· Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in adult patients with unstable bladder. source ↗

European Medicines Agency (CC BY 4.0). Events are matched to this condition by drug indication text — approvals/updates for drugs indicated for it, not disease-specific acts.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes6
  • Electric Stimulation Therapy1
  • Urethra1
  • Urinary Incontinence1
  • Urinary Incontinence, Stress1
  • Urinary Incontinence, Urge1
  • Wireless Technology1
Leading journals1
  • Nature communications1
Leading researchers8
  • Gao Q1
  • Kang N1
  • Lee CHT1
  • Liu M1
  • Ma C1
  • Shao L1
  • Shao Y1
  • Sitti M1
Affiliations (unnormalised)6
  • Global College1
  • Lee Kong Chian School of Medicine1
  • Max Planck Institute for Intelligent Systems1
  • Ruijin Hospital1
  • School of Electrical and Electronic Engineering1
  • School of Electrical Engineering1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Involuntary loss of URINE, such as leaking of urine. It is a symptom of various underlying pathological processes. Major types of incontinence include URINARY URGE INCONTINENCE and URINARY STRESS INCONTINENCE.

Identifiers
MeSHUrinary Incontinence
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.