Urinary Tract Infections
Recent clinical, regulatory, research and industry developments relating to this disease.
Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens.
Microbial co-occurrences on catheters from long-term catheterized patients.
Health-care-associated infection in Africa: a systematic review.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q2 2028.
- Q2 2028A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of U101 Oral Capsules in the Prevention of Uncomplicated Recurrent Urinary Tract Infections (rUTIs) in Women
- Q4 2028Clinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine Culture
Clinical MilestonesViewHide
- 2026-03-05Mechanisms of Successful Vaginal Estrogen Prophylaxis for Postmenopausal Women With Recurrent Urinary Tract Infections: Urogenital Microbiota and Host Immune ResponsesResults posted
- 2026-02-11A Phase 3b, Open-label, Single-arm Study in Adolescent and Adult Female Participants to Evaluate Clinical Symptom Improvement and the Safety of Gepotidacin During Treatment of Uncomplicated Urinary Tract Infections (Acute Cystitis)Results posted
- 2025-12-08Clinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine CultureResults expected Q4 2028
- 2025-09-22A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of U101 Oral Capsules in the Prevention of Uncomplicated Recurrent Urinary Tract Infections (rUTIs) in WomenResults expected Q2 2028
- 2026-08-01Bacterial Interference for Preventing Recurrent Urinary Tract Infection - New Ways of TreatmentPrimary completion
- 2026-08-01ClinicalBacterial Interference for Preventing Recurrent Urinary Tract Infection - New Ways of TreatmentPrimary completion
- 2026-03-05ClinicalMechanisms of Successful Vaginal Estrogen Prophylaxis for Postmenopausal Women With Recurrent Urinary Tract Infections: Urogenital Microbiota and Host Immune ResponsesResults posted
- 2026-02-11ClinicalA Phase 3b, Open-label, Single-arm Study in Adolescent and Adult Female Participants to Evaluate Clinical Symptom Improvement and the Safety of Gepotidacin During Treatment of Uncomplicated Urinary Tract Infections (Acute Cystitis)Results posted
- 2025-12-08ClinicalClinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine CultureResults expected Q4 2028
- 2025-09-22ClinicalA Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of U101 Oral Capsules in the Prevention of Uncomplicated Recurrent Urinary Tract Infections (rUTIs) in WomenResults expected Q2 2028
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Urinary Tract Infections3
- Catheter-Related Infections2
- Biofilms1
- Cross Infection1
- Drug Resistance, Multiple, Bacterial1
- Educational Status1
- Mendelian Randomization Analysis1
- Pneumonia1
Leading journals5
- Bulletin of the World Health Organization1
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America1
- Journal of global health1
- Nature communications1
- Pathogens (Basel, Switzerland)1
Leading researchers8
- Allegranzi B1
- Bagheri Nejad S1
- Bendali F1
- Bergeron K1
- Bouhrour N1
- Bradley SF1
- Caparon MG1
- Cardenas DD1
Affiliations (unnormalised)6
- Department of Molecular Microbiology and Center for Women's Infectious Disease Research1
- Key Laboratory of Surgical Critical Care and Life Support1
- Leiden University Medical Center1
- McGovern Medical School1
- the Second Affiliated Hospital of Xi'an Jiaotong University1
- Université de Bejaia1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Urinary tract infections are inflammatory responses of the urinary tract epithelium to microbial invasion. They are often bacterial infections and are associated with bacteriuria and pyuria.
The grounding supports microbial invasion as the immediate cause, most often by bacteria. Catheter-associated urinary tract infection is a recognized healthcare-associated form linked to urinary catheters and microbial contamination of the device surface.
The disease involves inflammation of the urinary tract epithelium in response to invading microorganisms. In catheter-associated infection, microorganisms can adhere to catheter surfaces and form biofilms, which protect them and promote persistence in the host.
Urinary catheter use is a major risk factor for catheter-associated urinary tract infection. The literature grounding also places these infections in hospital and long-term care settings, indicating healthcare exposure as an important epidemiologic context.
Management is described at the level of diagnosis, prevention, and treatment strategies for catheter-associated urinary tract infection. The grounding supports use of evidence-based approaches to reduce risk and to manage both symptomatic infection and asymptomatic bacteriuria, but does not specify drug classes or regimens.
AI-generated summary grounded in MeSH and 3 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.