Back to discover
Disease

Urolithiasis

Late-stage therapeutic development

Also known as calculus, urinary stones, kidney stone.

18
Clinical trials
12
Associated genes
5
Related proteins
Current focus
1 biologySerotransferrin biologyTherapeutic developmentDisease mechanisms & pathology

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 5 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones5View
Results expected 5
Activity timeline5

Clinical trials

15 sponsors · 4 new · 0 completed in the last 12 months (net +4)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
7
Late-stage
6
Completed
Late-stage studies

Efficacy of Oral Potassium Citrate in Reducing Ureteral Stent Encrustation Post-Ureteroscopy

Phase 2/3 · Active, not recruiting · Zagazig University

Effect of Perioperative Silodosin on Ureteric Dilatation in Retrograde Intrarenal Surgery

Phase 3 · Completed · Ain Shams University

The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation

Phase 4 · Completed · Mansoura University

Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain : a Randomized, Double Blind, Controlled Clinical Trial

Phase 4 · Completed · Pamukkale University

A Randomized Controlled Trial Assessing the Efficacy of Antimicrobial Prophylaxis for Extracorporeal Shock Wave Lithotripsy on Reducing Urinary Tract Infection

Phase 3 · Terminated · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Efectividad de la Tamsulosina Como Tratamiento Adyuvante Previo a Ureterolitotomia Endoscopica

Phase 4 · Terminated · Pontificia Universidad Catolica de Chile
Recruiting

Intravesical Aminophylline to Facilitate Semi-Rigid Ureteroscopic Access in Children With Lower Ureteral Stones: A Prospective Randomized Double-Blind Placebo-Controlled Trial

Phase 2 · Recruiting · Beni-Suef University

An International Multicenter Study on the Antimicrobial Prophylaxis Strategy for Flexible Ureteroscopic Lithotripsy Combined With a Flexible Negative Pressure Suction Sheath

N/A · Recruiting · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones: A Prospective Randomized Study

Phase 2 · Recruiting · Beni-Suef University

Intra-nasal Ketorolac Versus Oral Diclofenac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

Phase 1/2 · Recruiting · University of Texas Southwestern Medical Center

The Combined Effect of Antibiotic Irrigation and Aspiration Ureteral Access Sheath on Infectious Complications in Retrograde Intrarenal Surgery: A Prospective Randomized Factorial Study

N/A · Recruiting · Hitit University
Recently completed

A Randomized, Prospective, Single-Blinded Control Trial to Assess the Need for Antibiotic Prophylaxis With Routine Ureteral Stent Removal After Kidney Stone Procedure

N/A · Completed · University of California, San Diego

Comparison of Trifecta Analysis of Standard Versus Mini Percutaneous Nephrolithotomy in the Management of Urolithiasis

N/A · Completed · Hayat Abad Medical Complex, Peshawar

Effect of Perioperative Silodosin on Ureteric Dilatation in Retrograde Intrarenal Surgery

Phase 3 · Completed · Ain Shams University

Lime Powder Regimen Supplement Alleviates Urinary Metabolic Abnormalities to Prevent Urolithiasis Recurrence.

Phase 2 · Completed · Chulalongkorn University

The Predictors of Successful Oral Dissolution Therapy in Radiolucent Renal Stones; A Prospective Evaluation

Phase 4 · Completed · Mansoura University

Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain : a Randomized, Double Blind, Controlled Clinical Trial

Phase 4 · Completed · Pamukkale University

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

CYP24A10.45ABCG20.44BCAS10.43CLDN140.43DGKH0.43RGS140.43EPB41L20.42PDILT0.40LRRC4C0.39PTGER10.39DGKD0.38SLC34A30.38

Disease biology

5 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialvia CYP24A10.45Prostaglandin E2 receptor EP1 subtypevia PTGER10.39Proliferation marker protein Ki-67via MKI670.30Serotransferrinvia TF0.29C-C motif chemokine 2via CCL20.28

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.

Synonyms

calculus, urinary stones, kidney stone

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.