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Disease

West Nile Fever

Late-stage therapeutic developmentEmerging research
MeSHWest Nile Fever
2
Publications
10
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Addressing the rise of autochthonous vector-borne diseases in a warming Europe.

Research2024-10-19International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Evidence of Lineage 1 and 3 West Nile Virus in Person with Neuroinvasive Disease, Nebraska, USA, 2023.

Research2024-10-01Emerging infectious diseases

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones.
Clinical Milestones1View
Recently completed 1
Activity timeline1

Clinical trials

7 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
10
All trials
2
Active
1
Late-stage
6
Completed
Recently completed

Administering Convalescent Plasma Rich With Neutralizing Abs. to Hospitalized Adults With WNV - a Double-blind Randomized Controlled Study

Phase 3 · Completed · Sheba Medical Center

Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults.

Phase 2 · Completed · Sanofi Pasteur, a Sanofi Company

Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis

Phase 1 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults

Phase 2 · Completed · Sanofi Pasteur, a Sanofi Company

A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects

Phase 1 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis

Phase 1 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Addressing the rise of autochthonous vector-borne diseases in a warming Europe.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024 · 11 cites

Evidence of Lineage 1 and 3 West Nile Virus in Person with Neuroinvasive Disease, Nebraska, USA, 2023.

Emerging infectious diseases · 2024 · 8 cites
Recent publications

Addressing the rise of autochthonous vector-borne diseases in a warming Europe.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024 · 11 cites

Evidence of Lineage 1 and 3 West Nile Virus in Person with Neuroinvasive Disease, Nebraska, USA, 2023.

Emerging infectious diseases · 2024 · 8 cites
Major themes8
  • Aedes1
  • Climate Change1
  • Dengue1
  • Mosquito Vectors1
  • Phylogeny1
  • Vector Borne Diseases1
  • West Nile Fever1
  • West Nile virus1
Leading journals2
  • Emerging infectious diseases1
  • International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases1
Leading researchers8
  • Brault AC1
  • Cao LC1
  • Davis E1
  • Donahue M1
  • Eschliman J1
  • Fitzpatrick K1
  • Fleischmann WA1
  • Haley J1
Affiliations (unnormalised)3
  • Center for Infectious Diseases1
  • Institute of Medical Microbiology and Clinic for Infectious Diseases1
  • Institute of Tropical Medicine1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)

Identifiers
MeSHWest Nile Fever
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.